Diagnostics
A virus (from the Latin virus meaning toxin or poison) is a microscopic organism consisting of genetic material (RNA or DNA) surrounded by a protein, lipid (fat), or glycoprotein coat. Viruses are unique organisms because they cannot reproduce without a host cell. After contacting a host cell, a virus will insert genetic material into the host and take over the host"s functions. The cell, now infected, continues to reproduce, but it reproduces more viral protein and genetic material instead of its usual products. It is this process that earns viruses the classification of "parasite".
Health experts and politicians filled Sunday talk shows as Obama administration officials push for reform.
Australia"s general practices stand ready to work with Government to begin vaccinating vulnerable Australians against HINI (Swine Flu) as soon as a vaccine becomes available, the AMA said today.
More than 1,000 global experts will gather in Dubai from 8-9 November 2009 to review the latest developments and trends in anti-aging medicine at the second Dubai Congress on Anti-Aging & Aesthetic Medicine (DCAAAM).
Building on its widely distributed multiplex PCR technology platform, Seegene is now providing healthcare systems worldwide with a powerful diagnostic test for effective identification of the new influenza A virus (swine H1N1).
What"s Up, Docs? The Wall Street Journal
The U.S. will work to address the health challenges facing India among other countries and will aim to improve maternal and child health care services through comprehensive dialogue, Secretary of State Hillary Clinton said on Friday after visiting a Self Employed Women"s Association (SEWA) trade outlet in Mumbai, India, PTI/Yahoo! News reports. Clinton said, "Our government is already spending a lot of money on HIV/AIDS but we wanted to add maternal and child health to that commitment as it is important for India." She added that the funding will be used to combat tuberculosis and polio, "which are also problems in India" (7/18).
HIV infection rates among gay men and other men who have sex with men (MSM) in "some African countries are 10 times that of the general male population, and stigma, poor access to treatment or testing are to blame," according to a Lancet study published online on Monday, AFP/China Post reports. University of Oxford researchers looked at published studies to examine HIV prevalence rates between 2003 and 2009. "The difference varies a lot across Africa, but in most of the countries studied," MSM HIV prevalence rates "were substantially higher than among heterosexuals," writes AFP/China Post (7/20).
The AIDS Healthcare Foundation last week filed a petition in Los Angeles County Superior Court asking "the court to order the Los Angeles County Department of Public Health to enforce regulations that require condom use in adult-film production or take other reasonable steps to stem the spread of disease," the Los Angeles Times reports (Yoshino, 7/17). In the petition, "the group claims that in the month since an actress tested positive for HIV, the county Department of Public Health has done little to address what it considers to be a serious health threat" (AP/San Jose Mercury News, 7/16). In a statement released last week, the department, said, "The county continues to strongly support state legislation and the regulatory role of the [California Division of Occupational Safety and Health] as the most appropriate means to regulate the practices in the adult-film industry that expose performers to unnecessary and preventable occupational risks of acquiring and transmitting these diseases," adding, "The department does not believe that litigation is the best means to deal with this issue" (Yoshino, 7/17).
"The first clinical trial of an HIV/AIDS vaccine designed and developed in South Africa was launched in Cape Town" Monday, the SAPA/The Times reports. The trial will seek to determine the immune response of HIV-negative people to two experimental vaccines - SAAVI DNA-C2 and SAAVI MVA-C (7/20). Similar tests of the vaccine began in the U.S. earlier this year, the AP/Washington Post reports. According to Anthony Mbewu, president of South Africa"s government-supported Medical Research Council, the vaccine was designed at the University of Cape Town with technical help from the NIH, which also manufactured the vaccine (Faul, 7/20). Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called the partnership between South Africa and the U.S. "the most important AIDS research partnership in the world," but cautioned the years ahead would prove challenging as researchers test the safety and efficacy of the HIV vaccine, the AP/Google.com reports (Faul, 7/20).
Secondhand smoke (SHS) is not only a nuisance, but a potential health concern for many college students, and administrators should be taking steps to reduce students" exposure, according to a new study by researchers at Wake Forest University School of Medicine.
To control mosquito-borne diseases like dengue, researchers need to look
Mild facial nerve paralysis caused by the use of forceps during birth generally resolves on its own and does not require treatment, according to a report in the July issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals.
Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL), a specialty biopharmaceutical company, announced that new data from the two-part HYHYHI Study (Hypogonadal Hypotestosteronism in HIV-Seropositive Men) were presented as a poster today at the 5th International AIDS Society (IAS) Conference in Cape Town, South Africa. This retrospective chart review, supported by the Company, evaluated the challenges associated with diagnosing low testosterone in men with HIV/AIDS. The study also compared the difference in testosterone levels achieved after 12 months of treatment with either Testim® 1% (testosterone gel) or AndroGel®, two commonly used FDA-approved testosterone replacement products.
New research shows babies have a handle on the meaning of different dog barks - despite little or no previous exposure to dogs.
Women in Somerset now have a new of expert information and advice available to them as soon as they know they are pregnant.
Research at the Walter and Eliza Hall Institute into the mechanics of how two types of white blood cells grow and die is fundamentally changing the development of computer models that are used to predict how immune system cells respond to a pathogenic threat.
Spectrum Pharmaceuticals, Inc. (NasdaqGM: SPPI), a commercial stage biotechnology company with a focus on oncology, announced that the U.S. Food and Drug Administration (FDA) has accepted for filing and review the resubmission to the Company"s supplement to the biologics license application for ZEVALIN (ibritumomab tiuxetan) in the first line consolidation setting on July 8, 2009. The FDA considers the review as a Class 1 submission to their complete response letter of July 2, 2009. Therefore, the user fee goal date is September 7, 2009.
The risk of developing breast cancer due to taking hormone replacement therapy appears to be the same for women with a family history of the disease and without a family history, a University of Rochester Medical Center study concluded.
Provectus Pharmaceuticals, Inc. (OTC BB: PVCT ), a development-stage oncology and dermatology biopharmaceutical company, has initiated a new Phase 2 clinical trial of PH-10 for psoriasis involving daily dosing of patients for 28 days. After reviewing safety and efficacy data from its PH-10 trial for atopic dermatitis, Provectus determined that daily dosing of patients with psoriasis trial would be an appropriate and attractive regimen. The new study supplants an earlier Phase 2 study, using twice weekly dosing for 12 weeks, which was terminated earlier in June.
Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, announced that the Swiss agency for therapeutic products, Swissmedic, has issued a marketing authorisation for Moapar(R) 11.25mg, the first 3-month injectable formulation, prescribed for a reversible reduction of serum testosterone to the level of castration in adult men suffering from sexual deviations. Developed by Debiopharm, Moapar(R) contains a gonadotropin-releasing hormone (GnRH) agonist analogue.
There is no evidence that giving infants a combination vaccine for diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HBV), and Haemophilus influenza type B (Hib) protects them as effectively as separate vaccines, according to the results of a new Cochrane review.
Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth). The proof-of-concept study is published online in advance of print in Tissue Engineering Part A.
The UK needs a national plan for dementia research or the country will pay the price, the UK"s top scientists are warning today.
Revised guidelines on when and how to induce labor in pregnant women were issued by The American College of Obstetricians and Gynecologists (ACOG). The guidelines provide physicians with guidance regarding which induction methods may be most appropriate under particular circumstances, as well as the safety requirements, and risks and benefits of the different methods. ACOG"s Practice Bulletin "Induction of Labor" is published in the August 2009 issue of Obstetrics & Gynecology.
With the possibility of a major health care overhaul looming on the horizon, commentators, analysts and advocates have been seeking out points of comparison.
The Washington Post reports on efforts by hospitals to tally their avoidable mistakes and describes "hundreds of incidents of death or serious medical harm disclosed in the past year by hospitals in the Washington region, preventable errors that until recently have not required public reporting. Under laws that took effect last year in Virginia and a few years earlier in the District and Maryland, hospitals must report to health regulators many serious injuries that patients suffer in the course of treatment. The laws are different in each jurisdiction. For example, Virginia"s public records identify the hospitals by name, while Maryland"s and the District"s do not. But they all allow the public to glimpse the breadth of mistakes that health experts dub "never events" (because they should never happen): sponges left inside patients after surgery, operations on the wrong limb, medication errors, falls that lead to needless deaths (as well as other events). At least 20 states require hospitals to report every incidence of hospital-acquired infection. Patients, insurers and regulators are beginning to use this information to prod health-care providers to ensure that such events really never happen."
The Connecticut legislature used its override in both chambers to undo seven vetoes by the governor, including one to cover most Connecticut residents, called SustiNet, The Hartford Courant reports: "Senate Majority Leader Martin Looney said that healthcare, "in many ways, has become a cloud of worry"" over much of society. SustiNet"s nine-member board of directors will study the issue (covering people and cost) for 17 months before giving its recommendations to the legislature in January 2011" (Keating, 7/20).
Over 30 of the UK"s leading scientists have signed an open letter to the government calling for more public money to back research into dementia,
Nigeria on Monday signed on to receive a $100 million loan from the World Bank for malaria control activities, Leadership Nigeria reports. The states of Akwa Ibom, Anambra, Bauchi, Gombe, Jigawa, Kano and Rivers will receive part of the funding for malaria control activities (Nduwugwe, 7/21).World Bank Country Director for Nigeria Onno Ruhl signed the agreement on behalf of the bank and Nigerian Finance Minister Sarki Muhtar signed on behalf of the federal government. Ruhl said the World Bank is "confident" in Nigeria"s ability to fight malaria, This Day writes. Ruhl pointed out that during President Barack Obama"s recent trip to Ghana, he "commended" Nigeria"s interfaith efforts for fighting malaria.
Health reform legislation moving through the U.S. House of Representatives would reverse the continued and growing loss of health coverage by American families and would give millions of Americans the security of stable, quality, affordable coverage, according to a report released today by the consumer health organization Families USA.
A pilot needle exchange program in Camden, N.J., - one of four in the state - "was off to a slow start" when it began 18 months ago, but "now, 976 drug users have registered with the program - more people than those at the other pilot sites in Atlantic City, Newark or Paterson," the Cherry Hill Courier-Post reports. "In Camden, 854 people are living with HIV/AIDS, the eighth-highest number among New Jersey municipalities, according to the latest data from the state Department of Health and Senior Services. About a third of them were infected by dirty needles," the Courier-Post reports. Bob Baxter, who oversees Newark"s program, said needle exchanges provide "the most immediate benefit at the cheapest cost," in reducing the spread of blood-borne diseases. "While there"s no way to count the number of people who are no longer sharing needles because of the program, organizers say they hope to see their success correlate to lowered communicable disease rates," the article states (Hirsch, 7/20).
Patients would spend less time waiting for medical testing and treatment if the Government introduced Medicare rebates for GP-referred MRI (Magnetic Resonance Imaging) and diagnostic testing in GP surgeries, the AMA said today.
Five organizations representing the nation"s experts in infectious diseases medicine, infection prevention in healthcare settings, and public health and disease prevention announced their support for a provision requiring national reporting of healthcare-associated infection (HAI) rates, which is contained within the healthcare reform bill introduced by leaders of the U.S. House of Representatives.
Long Beach PET Imaging Center, a leading diagnostic imaging center in the Long Beach, Calif.-area, announced it has relocated to a new, expanded facility at 2708 East Willow, Signal Hill, CA 90755, 562-427-0714, adjacent to Liberty Pacific Medical Imaging. The relocation is expected to be completed in August 2009. During the relocation process, all services including PET/CT and CT will remain in full operation without any interruption.
A team of researchers from the Yale University (United States) and a Spanish company have developed a system to detect the vapours emitted by human skin in real time. The scientists think that these substances, essentially made up of fatty acids, are what attract mosquitoes and enable dogs to identify their owners.
SRI International, an independent nonprofit research and development organization, has announced that SRI"s Center for Cancer Research was selected by the National Cancer Institute (NCI) for a leading role in the newly-formed "Chemical Biology Consortium" (CBC), a collaborative drug discovery partnership focused on advancing new cancer therapeutics active against novel molecular and genetic cancer targets. Based on its track record of cancer drug discovery and development, SRI was chosen to lead three of the CBC"s research and development centers: Comprehensive Chemical Biology Screening, Chemical Diversity, and Specialized Applications.
Several cerebrospinal fluid (CSF) biomarkers showed good accuracy in identifying patients with mild cognitive impairment who progressed to Alzheimer disease, according to a study in the July 22/29 issue of JAMA.
Adherence to modifiable lifestyle and dietary factors including maintaining normal weight, daily vigorous exercise, eating a diet high in fruits, vegetables, low-fat dairy products and low in sodium and taking a folic acid supplement was associated with a significantly lower incidence of self-reported hypertension among women, according to a study in the July 22/29 issue of JAMA.
The National Neutropenia Network (NNN) and the Severe Chronic Neutropenia International Registry (SCNIR) will host the 9th Annual Neutropenia Family Conference in Ann Arbor, Mich., on July 24-26, at the Marriott Ypsilanti at Eagle Crest.
Researchers from Cincinnati Children"s Hospital Medical Center have discovered that a specific gene - Sox17 - plays an important role in directing cells to become part of the pancreas or part of the bile duct (used in the digestion of food).
Merz Pharma Canada Ltd. announces new XEOMIN® (Botulinum neurotoxin type A) is now available for prescribing to patients with the following serious, debilitating neuromuscular conditions:
Today the National Business Coalition on Health (NBCH) released a national report on efforts of health plan programs to improve cardiovascular disease (CVD) care and prevention. NBCH used data from eValue8(TM), the nation"s leading standardized Request for Information (RFI), a tool utilized by employers and coalitions to measure and compare health plan performance.
The United States will start human trials of an experimental vaccine for preventing the 2009 H1N1 influenza virus in August; the first
Advocates are stepping up efforts to address the high pregnancy rate among teens in foster care programs, Time reports. Although teen pregnancy rates are rising nationwide after years of declines, the numbers in the foster care system are "truly epidemic," according to Time. A University of Chicago study showed that almost half of girls who have spent time in the foster system had been pregnant at least once before age 19, and almost one-fourth had multiple pregnancies in their teens. However, the problem has traditionally received scant attention from children"s health advocates. Last week, the Planned Parenthood Federation of America and the National Campaign To Prevent Teen and Unplanned Pregnancy announced a new campaign to address pregnancy prevention for foster care teens. The groups plan to push the Obama administration to consider the issue as it develops strategies to prevent unintended pregnancies. Planned Parenthood is recruiting and training thousands of peer educators -- including many who are in foster care themselves -- to engage teens in medically accurate discussions about sex. A report released this week by the National Campaign shows that nearly half of the 500,000 children in foster care had sex for the first time before age 16, compared with 30% of all teens. Teens in foster care also were more likely to have had forced sex and less likely to have used contraception.National Campaign Senior Policy Director Andrea Kane said, "Foster parents already go through trainings -- the delivery system exists." She added, "[W]e have people who can teach them how to do this. We just need to put the two together." According to Time, foster parents might assume that children were taught about reproductive health while living with another family. Social workers might also be reluctant to discuss sex with foster children. Advocates say that intended pregnancy also should be addressed as part of prevention efforts. University of Chicago researcher Amy Dworsky said, "For some foster youth, having a child is a way to create a family that they don"t have, or to fill an emotional void" (Sullivan, Time, 7/22).
Women who underwent radiation therapy for cancer as children have an increased long-term risk for developing breast cancer, according to a study published in the Journal of Clinical Oncology, Reuters reports. However, when the childhood treatments included a high dose of radiation to the ovaries, women"s risk of developing future breast tumors was "sharply reduced," according to the study.For the study, Peter Inskip of the National Cancer Institute and colleagues examined 120 women diagnosed with cancer before age 21. All women in the study were treated with radiation between 1970 and 1986 and survived at least five years. The women were compared with four women who also were diagnosed at a young age but did not receive radiation.The study found that the more radiation a woman received as a child, the more likely it was that a tumor would eventually develop. The study did not find that chemotherapy for the first cancer increased the risk for a second cancer (Reuters, 7/20).
"Americans are showing more confidence in their ability to get and afford the health care they need, according to a poll released Tuesday," The Associated Press reports on Cleveland.com. The story continues: "Whites, though, are likelier to feel that way than minorities. And large numbers of people are worried about whether they will have future health coverage, with nearly one in four concerned that family medical bills will drive them into bankruptcy."
At a time when the entertainment industry is perpetuating inaccurate portrayals of nursing in the new television shows "Nurse Jackie" and "HawthoRNe," ANA"s ethics books are especially relevant to all registered nurses (RNs). The fictional nurses are shown violating the nursing Code of Ethics by participating in activities ranging from on-the-job drug use to inappropriate nurse/patient contact in these shows. The very heart of nursing is mischaracterized as nurses are portrayed engaging in irresponsible and often criminal acts for entertainment purposes. ANA sets the ethical standards for nurses in the U.S. and internationally with its highly respected Code of Ethics for Nurses with Interpretive Statements, and is deeply concerned about the lasting impact these negative portrayals may have on the nursing profession.
Young adults are facing tough times with limited job prospects and no health insurance. The Associated Press reports on recent college graduate Emily Weinstein as being representative of the many young uninsured Americans: "Like millions of other uninsured adults in their 20s, Weinstein is watching Congress as it advances legislation to overhaul health care. The recession has deepened young adults" career struggles. It has also sharpened their interest in health insurance. Already the least likely of any age group to have coverage, adults in their 20s face brutal job searches and more time uninsured because of the recession. Nearly 30 percent, 13.2 million, were uninsured in 2007, according to the Commonwealth Fund, a New York-based research center. Many young adults work entry-level jobs without insurance and, despite new laws in some states, they"re eventually too old to stay on their parents" policies."
Giving daily antiretroviral syrup to breastfeeding infants or treating their HIV-infected mothers with highly active antiretroviral drugs is safe and effective in preventing mother-to-child HIV transmission through breast milk, a study led by University of North Carolina at Chapel Hill investigators has found.
Proteus syndrome is a complex disorder associated with varied, disproportionate, asymmetric overgrowth of many body parts and unregulated adipose tissue. The overgrowth seen in Proteus syndrome is progressive and difficult to manage. Patients with Proteus syndrome require repeated treatment for the progressive overgrowth of tissue over a long period. Aggressive treatment may cause severe functional and cosmetic consequences, so surgical intervention is often delayed until it is absolutely necessary.
Nothing could be easier than walking out the door, right? According to a new University of Illinois journal article, an abused woman actually goes through a five-step process of leaving that can be complicated at every stage by boundary ambiguity.
Funding from the American Recovery and Reinvestment Act will allow the National Institutes of Health to create jobs for early career scientists and increase the ranks of researchers and clinicians working in the global health field. With $3 million in funding over the next 18 months, the NIH"s Fogarty International Center will be able to support 23 additional participants in its Clinical Research Training Scholars and Fellows Program.
Illumina (NASDAQ:ILMN) announced that the Genomic Medicine Institute (GMI) at Seoul National University College of Medicine in Korea, purchased seven additional Illumina Genome AnalyzerIIx sequencing systems, expanding the capacity of their recently established Asian Genome Center to 10 Illumina sequencing systems.
Applying biological molecules from cell membranes to the surfaces of artificial materials is opening peepholes on the very basics of cell-to-cell interaction.
Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.
A breakthrough technology adapted for breast cancer detection based in part on research originally sponsored by the Office of Naval Research (ONR) is set to air July 23 during a CNN International news segment on Vital Signs, a program hosted by Dr. Sanjay Gupta.
The National Cancer Institute has awarded a five-year, $2.8 million Research Project (RO1) grant to Roswell Park Cancer Institute http://www.roswellpark.org/ (RPCI) researchers to investigate the role of immunological pathways in the development of ovarian cancer.
Every hour of the day children are inactive adds three minutes to the time it takes them to fall asleep, finds research published ahead of print in Archives of Disease in Childhood.
The increasing incidence of terrorist attacks means that doctors in civilian settings, as well as those in combat operations, need training on blast injuries. The issues surrounding these frequently devastating injuries are discussed in a Seminar published Online First and in an upcoming edition of The Lancet, written by Dr Stephen Wolf, Department of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA, and colleagues.
The accepted dogma has been that bone-forming cells, derived from the body"s connective tissue, are the only cells able to form the skeleton. However, new research shows that specialized cells in the blood share a common origin with white blood cells derived from the bone marrow and that these bloodstream cells are capable of forming bone at sites distant from the original skeleton. This work, published online this month in the journal Stem Cells, represents the first example of how circulating cells may contribute to abnormal bone formation.
A research published ahead of print in the British Journal of Ophthalmology suggests certain types of drugs prescribed to lower blood pressure seem to increase the risk of corrective cataract surgery.
The National Changing Diabetes((R)) Program (NCDP), a program of Novo Nordisk, and several member associations today urged President Obama and members of Congress to make the prevention, detection and treatment of diabetes, one of the nation"s most pervasive and costly diseases, a priority in reforming the U.S. healthcare system.
New European Union (EU) regulations restricting use of animals to test the safety of shampoo, nail polish, and other personal care products are forcing cosmetic makers to seek alternative ways to test these products, according to an article scheduled for the May 11 issue of Chemical & Engineering News, ACS" weekly newsmagazine.
The World Health Organization is reviewing its 2006 guidelines on the use of antiretroviral drugs by HIV-positive pregnant and breastfeeding women because of new evidence that prolonged use can cut the risk of mother-to-child transmission, Reuters reports. Current guidelines recommend that these women receive a short-course antiretroviral regimen. However, a new study released at an international AIDS conference on Wednesday shows that a stronger regimen over a prolonged period significantly lowers the risk of mother-to-child transmission.The study examined 824 pregnant women in Burkina Faso, Kenya and South Africa who received either the standard antiretroviral regimen or a combination of three antiretrovirals. The combination regimen was administered during the last trimester and for a maximum of six months during breastfeeding, according to study leader Tim Farley of WHO"s Department of Reproductive Health. Farley said women who received the combination regimen during pregnancy, delivery and breastfeeding had a 42% lower risk of transmitting HIV to their infants than women given the standard course.Farley added, "The results of this study show an almost twofold reduction in the risk of HIV transmission during the breastfeeding period and also [show] there is no short-term toxicity" to the women or their infants. He said that participants will be monitored for any long-term health effects. WHO is expected to release the updated recommendations by the end of the year (Roelf, Reuters, 7/21).
As healthcare reform becomes an increasing national priority, the American Psychological Association (APA) and YMCA of the USA announced a partnership that provides strategies to help families improve their overall well-being and physical health, and advocates for a comprehensive healthcare system that has a strong approach to chronic disease prevention. The partnership will specifically address the impact individual behaviors such as eating healthy and increasing physical activity can have in reducing risk factors for chronic diseases.
Patients with moderate COPD were randomized to receive "usual care" or to undergo an interdisciplinary, community-based program (INTERCOM) that offered an intensive lifestyle moderation phase of four months, during which patients were instructed in detail to perform two 15-minute intervals of pleasurable walking or cycling, and offered instruction in other lifestyle changes such as nutrition and smoking cessation. After the four-month introductory period, there was a less intensive 20-month maintenance during which patients were offered guidance but not intensive intervention.
Medtronic, Inc. (NYSE: MDT) announced that the U.S. Food and Drug Administration (FDA) has classified its voluntary recall action of the Intrepid™ Intervertebral Body Fusion Device as a Class II recall. Medtronic initiated a voluntary recall of the product on February 6, 2009, and communicated the risk to physicians and hospitals. As of the date of this news release, all unused product has been retrieved and Medtronic has received confirmation of notification from all affected physicians and hospitals.
USA Today reports that three years after mandating coverage for all, Massachusetts is emerging as national model.
The race to develop a H1N1 (swine flu) vaccine before the fall flu season ramped up Wednesday, after Australia launched the first human trials of the H1N1 vaccine and scientists from the U.S., China and Britain announced plans for human trials of an H1N1 vaccine in coming weeks, AFP/France24.com reports (7/23).
Vitamin D may slow the progressive decline in the ability to breathe that can occur in people with asthma as a result of human airway smooth muscle (HASM) proliferation, according to researchers at the University of Pennsylvania.
Patients who added Merck"s HIV drug Isentress to their regular daily HIV drug regimen "fared no better than those who added a placebo to the mix," as the drug failed to "reduce low-level reservoirs of HIV," in the body, according to findings presented at the International AIDS Society conference in Cape Town, South Africa, Bloomberg reports. As part of the 53-participant study led by Harvard University, researchers looked at patients whose viral loads were at undetectable levels and "were given either Isentress or a placebo for 12 weeks, then switched to the alternate agent for an additional 12 weeks. The study found no difference in low levels of the virus between the two groups, using a highly sensitive test," the article states. "The results are a setback for doctors looking for ways to seek and destroy the last vestiges of HIV, which aren"t reached by currently available drugs. Eliminating these so-called viral reservoirs may potentially cure patients, allowing them to stop taking daily medicines," according to Bloomberg (Pettypiece, 7/22).
Uncooked meat products enhanced with food additives may contain high levels of phosphorus and potassium that are not discernable from inspection of food labels, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). This can make it difficult for people to limit dietary phosphorus and potassium that at high levels are harmful to kidney disease patients.
Case Western Reserve University School of Medicine has received a $3.7 million grant from the National Institutes of Health to determine if painful bladder syndrome may be caused by abnormalities in the autonomic nervous system rather than in the bladder itself.
In a paper publishing online July 23 in Cell Stem Cell, a Cell Press journal, Dr. Shaorong Gao and colleagues from the National Institute of Biological Sciences in Beijing, China, report an important advance in the characterization of reprogrammed induced pluripotent stem cells, or iPSCs.
Taking photographs or video of unusual symptoms on an ordinary camera phone can help doctors diagnose uncommon problems, say researchers in an article published on bmj.com.
US researchers have created "bacterial computers" with the potential to solve complicated mathematics problems. The findings of the research, published in BioMed Central"s open access Journal of Biological Engineering, demonstrate that computing in living cells is feasible, opening the door to a number of applications. The second-generation bacterial computers illustrate the feasibility of extending the approach to other computationally challenging math problems.
Women who are at risk for heart disease and who are also experiencing menopause symptoms now have an added re a highly specialized clinic in the Division of Cardiology at the Cedars-Sinai Heart Institute. The Advanced Preventive Women"s Clinic at the Women"s Heart Center recently opened and is offering comprehensive cardiac risk assessments designed specifically for women who are in menopause. The clinic also offers menopausal patients state-of-the-art screenings, as well as personalized medicine therapies and counseling, including high-risk hormone counseling.
Need another reason to commit to a healthy diet and exercise? Think migraines are just headaches? Migraine and obesity sufferers feel more emotional pain than those dealing with life-threatening conditions like congestive heart failure, prostate cancer, osteoporosis and high blood pressure. In fact, they tend to feel more pessimistic than those diagnosed with depression.
Open Monoclonal Technology, Inc. (OMT), in collaboration with Sangamo BioSciences, Inc. (NASDAQ, SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), The Medical College of Wisconsin, and INSERM, have announced the creation of the first targeted knockout rats as detailed in "Knockout Rats Produced via Embryo Microinjection of Designed Zinc Finger Nucleases," published in the July 24th issue of Science. The creation of rats with permanent, heritable genetic mutations is a critical milestone in the development of OMT"s novel human monoclonal antibody platform.
"If you could read my mind, love, what a tale my thoughts could tell" - Gordon Lightfoot
Pictures paint concepts of a thousand words - now, for the first time, scientists studying the brain have worked out how words paint concepts in our minds.
When Tony Goldberg is not whacking through the brush of central
Innovative research conducted by faculty of the University of Pittsburgh Schools of the Health Sciences contributes to a better understanding of the causes and origins of disease and aids in the development of more effective treatment approaches. Government and private-sector funding is critical to this process of scientific inquiry. The following projects recently have been awarded grants that will enable the continuation of existing projects or the pursuit of new areas of investigation:
Speaking at a meeting of the New
Regeneron Pharmaceuticals, Inc. (NASDAQ:REGN) announced that the first patient has been enrolled in the Phase 3 program of VEGF Trap-Eye for the treatment of central retinal vein occlusion (CRVO), a leading cause of blindness in adults. Regeneron received a $20 million milestone payment from Bayer Healthcare that was triggered by the dosing of the first patient in the CRVO program. Regeneron also announced that enrollment in the Phase 2 DA VINCI study of VEGF Trap-Eye in diabetic macular edema (DME) has been completed and data are expected during the first half of 2010.
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its wholly owned subsidiary, BiPar Sciences, announced the initiation of the pivotal Phase III trial for BSI-201 in combination with chemotherapy in patients with metastatic triple-negative breast cancer (mTNBC), defined by tumors lacking expression of estrogen, progesterone receptors and without over-expression of HER2. BSI-201 is a novel investigational targeted therapy which inhibits poly (ADP-ribose) polymerase (PARP1), an enzyme involved in DNA damage repair.
Type 1 diabetes is the most common chronic childhood disease. The management of this serious medical condition includes regular fingerstick glucose measurements, multiple daily injections of insulin, and frequent insulin dose adjustments. Because children spend a great deal of their time in school, school nurses often supervise medical decisions and diabetes care. Some researchers believe that the use of telecommunication technology may make diabetes care easier for some children. A new study soon to be published in the Journal of Pediatrics explores the effectiveness of telemedicine in helping school nurses and children manage diabetes care.
"President Barack Obama arrived at the Cleveland Clinic without fanfareò€¦ Thursday afternoon" to visit the medical center he"s called a model of low-cost, high-quality care, the Cleveland Plain Dealer reports. Obama said he wasn"t seeking an endorsement from the hospital, only information. "There has been a lot of discussion in Washington about the very different model that we and the Mayo [Clinic] have, and he wanted to understand it better," Clinic CEO Dr. Delos "Toby" Cosgrove said (Zeltner and Townsend, 7/24).
The Brook Community Newspapers/Connecticut Post profiled New York researcher Jeffrey Laurence, who "helped at the outset to fully identify" HIV along with French virologist Luc Antoine Montagnier and others. Laurence, now of the Weill Cornell Medical College Laboratory for AIDS Virus Research at the New York Blood Center, in 1984, "published a paper with Montagnier in the New England Journal of Medicine that brought the news that their virus was the cause of AIDS," the article states. Since the discovery Laurence has continued his research seeking to develop a cure or vaccine for the virus, which now includes investigating the role of stem cells. He said, "The technology is too young to try to say we can cure someone of AIDS or of cancer. We need money to know how to engineer, to refine stem cells to be resistant to infection." The article states, "Laurence is pleased however, that President Barack Obama is "kinder on stem cells and is releasing some of the restrictions,"" on stem cell research (Semmes, 7/24).
In a study released online on July 22 in the journal Proceedings of the Royal Society: Biological Sciences, researchers at Arizona State University and Princeton University show that ants can accomplish a task more rationally than our - multimodal, egg-headed, tool-using, bipedal, opposing-thumbed - selves.
Half of all Americans will be diagnosed at some point in their lives with cancer, the number two killer in the United States. One of the most common types, especially among women, is breast cancer. According to the National Cancer Institute, 192,370 women will be diagnosed with breast cancer in 2009, and more than 40,000 women will die from the disease this year alone.
The results of a national assessment of indoor location systems for firefighters and other first responders will be announced at Worcester Polytechnic Institute (WPI) during the 2009 Workshop on Precision Indoor Personnel Location and Tracking for Emergency Responders, which runs from Aug. 3 to 4. The assessment was conducted by WPI researchers this spring with funding from the Department of Homeland Security and oversight from the U.S. Army Natick Soldier Research, Development, and Engineering Center (NSRDEC).
Andy Catling, PhD, Associate Professor in the Department of Pharmacology and the Stanley S. Scott Cancer Center at LSU Health Sciences Center New Orleans, has been awarded a $177, 500 supplement to his RO1 grant by the National Institute of General Medical Sciences to support his research on the mechanism by which seemingly similar cell receptor systems determine quite different functions influenced by hormones and drugs.
The Canadian Food Inspection Agency (CFIA), in collaboration with stakeholders, trading partners, and the public and animal health communities, has refined its approach to managing cases of the pandemic H1N1 2009 virus in swine.
Several state and local agencies, hospitals and others conducted a full-scale exercise involving
A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson"s disease for Vietnam veterans. The report is the latest in a congressionally mandated series by the IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin -- TCDD -- that contaminated some of the defoliants.
UCB announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending that the European Commission grant marketing authorisation for Keppra® as adjunctive treatment of partial-onset seizures in infants and young children aged one month to under four years.
African-American adolescents have some of the highest rates of HIV infection in the United States, and efforts to educate them about preventing the disease must include the help of their adolescent peers, new research suggests.
Merck Sharp & Dohme Limited (MSD) received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) recommending expanded marketing authorisation for "Isentress" (raltegravir) in combination with other antiretroviral (ARV) medicinal products for the treatment of HIV-1 infection in all appropriate adult patients, including patients starting HIV therapy for the first time (treatment-naç¯ve), as well as treatment-experienced patients. The positive opinion will be reviewed by the European Commission, which grants marketing authorisation to the 27 countries that are members of the European Union (EU), as well as Iceland and Norway.
A shocking 1 in 10 people say they have had unprotected sex because they were too embarrassed to buy condoms from a pharmacy.
The Royal Pharmaceutical Society of Great Britain has published its fourth Pharmacy
Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), announced the publication in Fertility and Sterility of data from a Phase 3 clinical study that showed that the investigational compound bazedoxifene/conjugated estrogens (BZA/CE) significantly reduced the frequency and severity of hot flushes and improved measures of vaginal atrophy when compared to placebo. In this study, uterine bleeding was not statistically different from placebo and the rate of endometrial hyperplasia in doses being considered for therapeutic use was Fertility and Sterility, is from the Selective estrogens Menopause And Response to Therapy (SMART-1) clinical trial. SMART-1 was designed to explore the hypothesis that bazedoxifene, when paired with conjugated estrogens, may have the potential to eliminate the need for progestin in menopausal therapy in women with an intact uterus. BZA/CE is characterized by Wyeth as a TSEC (tissue selective estrogen complex) as it combines a selective estrogen receptor modulator (SERM) with conjugated estrogens.
Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced that it has shipped the first doses of the 2009-2010 formulation of Fluzone((R)), Influenza Virus Vaccine. Fluzone vaccine is indicated for active immunization in people 6 months of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the seasonal influenza vaccine. Fluzone vaccine is the only vaccine licensed in the United States for children as young as 6 months of age through adults.
Crack open the latest medical textbook to the chapter on type 2, or adult-onset, diabetes, and you"ll be hard pressed to find the term "immunology" anywhere. This is because metabolic conditions and immunologic conditions are, with a few exceptions, distant cousins.
On 28th July Eric Page will take his place on Trafalgar Square"s Fourth Plinth for an hour from 10-11am as part of Antony Gormley"s One & Other exhibition Eric will spend part of his hour on the Plinth wearing a "THIVK you"re still negative?" t-shirt to raise awareness of the work of Terrence Higgins Trust. THIVK is a year long campaign developed by the CHAPS partnership and launched by THT to get men to consider if they have HIV without realising. The Health Protection Agency estimates up to 10,000 gay men in Britain have HIV without knowing.
Democrats are planning to push the point this week that health care reform, with a price tag of up to $1.6 trillion, has benefits and cost savings that aren"t scored by the Congressional Budget Office, The Hill reports.
Dr. Chong Yuan, Managing Director of Diazyme Laboratories Division, General Atomics, received the 2009 Pacific Biometrics Research Foundation Award at the annual meeting of American Association for Clinical Chemistry (AACC) held in Chicago on July 20th, 2009.
"Massachusetts legislators this year have filed a flurry of bills - more than 70 in all - that, if passed, would substantially expand the medical services insurers are required to cover for patients but also potentially raise healthcare costs," The Boston Globe reports. "The cascade of proposals to mandate coverage is up 50 percent from last year, and comes amid unprecedented scrutiny of healthcare spending. Among the bills are proposals to mandate coverage of hearing aids for children, treatments to fix cleft palates, wigs for patient who suffer "hair loss from cancer and other illnesses," and aquatherapy." Some say this level of activity may be caused by patient advocates "racing to get their health concerns covered by law before the state"s system for paying doctors and hospitals is overhauled." But given the state"s current budget difficulties, "it"s uncertain how many of the bills will make it into law" (Lazar, 7/27).
In New Hampshire, Foster"s Daily Democrat reports: "As unemployment statistics increase and the economic climate deteriorates, a large group of people who would otherwise likely not need mental health services are finding themselves at an increased risk for depression, anxiety, compulsive behaviors and substance abuse, according (to) the Substance Abuse and Mental Health Services Administration, a division of the U.S. Department of Health and Human Services."
The Health-Care Sacrifice The Washington Post
The Oakland, Calif., chapter of the National Coalition of 100 Black Women on Saturday held a daylong conference, "Sistahs Getting Real About HIV/AIDS," that addressed HIV/AIDS among black women, the San Francisco Chronicle reports. The conference "focused on two issues that might seem contradictory: first, to convince women that they must take special precautions to protect themselves, and second, to let them know that an HIV diagnosis is not a death sentence," according to the Chronicle. Keynote speaker of the conference Tony Wafford, director of health and wellness for the National Action Network, said black women need to be more vocal with their partners about practicing safe sex and getting tested for HIV. Organizers noted that black women also "must address the stigma associated with HIV before they can talk openly about the risk of infection with their partners," the article states (Allday, 7/25).
The AMA has congratulated the National Health and Hospitals Reform Commission on its final report launched in Canberra by Prime Minister Kevin Rudd.
A new report, "The Intelligent Board 2009: Commissioning to reduce inequalities", produced by an independent reference group of experts, encourages Primary Care Trust (PCT) Boards to review their understanding of health inequalities in their communities so that they can be addressed.
A lack of sunlight is associated with reduced cognitive function among depressed people. Researchers writing in BioMed Central"s open access journal Environmental Health used weather data from NASA satellites to measure sunlight exposure across the United States and linked this information to the prevalence of cognitive impairment in depressed people.
Long-term survivors of cancer that developed in adulthood are at increased risk of experiencing serious psychological distress, according to a report in the July 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Researchers have devised a scheme for identifying genes in yeast that
The University of Southern Nevada (USN) College of Nursing has been granted provisional approval by the Utah Board of Nursing to begin offering its 18-month Bachelor of Science in Nursing (BSN) program at the university"s campus located 10920 South River Front Parkway in South Jordan.
Evidence buried in the chromosomes of animals and plants strongly suggests only one group -- mammals -- have seen their genomes shrink after the dinosaurs" extinction. What"s more, that trend continues today, say Indiana University Bloomington scientists in the first issue of a new journal, Genome Biology and Evolution.
The Vermont Legislature has passed legislation (S 48) that bans nearly all gifts from pharmaceutical and medical device companies to health care providers, administrators and facilities in the state, the New York Times reports. The legislation specifically would prohibit drug and device makers from giving providers no-cost meals. Vermont"s legislation would go further than similar laws in other states like Massachusetts and Minnesota by requiring drug and medical device manufacturers who give gifts to health providers to publicly disclose recipients" names and dollar amounts of payments and gifts. The measure would not require manufacturers to disclose payments for clinical research of products undergoing FDA review, the Times reports. The legislation also would eliminate a loophole that allows manufacturers to conceal certain expenses by claiming them as trade secrets. In a recent report, the Vermont Office of the Attorney General said that medical product makers spent about $2.9 million on promotional efforts to the state"s health care providers in fiscal year 2008 and that nearly half of the state"s 4,573 licensed providers had received some type of incentive from drugmakers in the same year. The report, which was developed prior to passage of the new legislation, offers only aggregate data, as 83% of the manufacturer-declared payments were deemed to be trade secrets, the Times reports.Gov. Jim Douglas (R) is expected to sign the law, which would take effect July 1. Several state medical groups -- including the Vermont Association for Mental Health and the Vermont Medical Society -- have indicated support for the legislation.Marjorie Powell, a senior lawyer for the Pharmaceutical Research and Manufacturers of America, said the requirements under the new law appear redundant with new voluntary guidelines the group has issued on physician gifting practices. She said, "We think this is unnecessary, and it is not going to improve patient care," adding, "It makes it onerous not only for the company but also for the physician in Vermont, because this is going to be on a Web site" (Singer, New York Times, 5/20).
Taro Pharmaceutical Industries Ltd. reported that it has received approval from the U.S. Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for cetirizine hydrochloride tablets (OTC), 5 mg and 10 mg ("Cetirizine Tablets"). The product will be marketed by Taro"s U.S. affiliate, Taro Pharmaceuticals U.S.A., Inc.
CSL Biotherapies, a subsidiary of one of the world"s leading manufacturers of thimerosal-free seasonal influenza vaccine, announced that it has begun shipment of its seasonal influenza virus vaccine to a national network of U.S. distributors for the 2009-2010 season. CSL Biotherapies plans to deliver more than eight million doses of the vaccine, the majority of which will be in single-dose, thimerosal-free, pre-filled syringes.