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Merck's Gardasil Effective At Preventing HPV, Cervical Disease In Older Women, Study Finds
Merck"s human papillomavirus vaccine, Gardasil, was 90% effective in preventing infection with the virus and cervical disease in women ages 24 to 45, according to a study published Monday in the medical journal Lancet, Reuters reports (Fox, Reuters, 6/1). In the U.S., the vaccine currently is FDA-approved for girls and women ages nine to 26. Centers for Disease Control and Prevention guidelines recommend routine three-dose vaccination of girls ages 11 and 12 and for girls and women ages 13 to 26 who have not yet been vaccinated (CDC fact sheet, June 2008). It is designed to protect against HPV types 16 and 18, which cause about 70% of all cervical cancer cases, and HPV types 6 and 11, which cause genital warts.The new study, led by Nubia Munoz of the National Institute of Cancer in Bogota, Colombia, and funded by Merck, involved women ages 24 to 45 with no history of cervical disease or genital warts who either received the vaccine or a placebo injection. The study found that women who received the vaccine were significantly less likely to be infected with certain strains of HPV than those who received placebo shots. According to the researchers, four women out of 1,900 who received the vaccine developed HPV or cervical disease after two years, compared with 41 women out of 1,900 in the placebo group.Reuters reports that the results of the study could help Merck as it seeks approval for marketing Gardasil for use in older women. The researchers said in the study that older women might be at risk for HPV infection as "[c]hanges in sexual behavior during the past 30 years ... have led to more widespread premarital sexual intercourse and acquisition of new sexual partners around middle age." They added, "As the potential for HPV infection and disease exists in women in their third, fourth and fifth decades of life, these women could benefit from prophylactic HPV vaccination." According to Reuters, a mathematical model published in October 2005 showed that vaccinating older women could cut rates of cervical cancer in women through age 45 by half. Merck also has released data showing the effectiveness of the vaccine in preventing genital lesions in men.According to the Centers for Disease Control and Prevention, HPV is the most common sexually transmitted infection worldwide, and about 20 million U.S. residents are infected with it. The virus is the leading cause of cervical cancer, which causes about 3,870 deaths in the U.S. and 300,000 deaths globally every year, and it also can cause anal, penile, mouth and neck cancer (Reuters, 6/1).
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ZymoGenetics Reports Encouraging Preliminary Results From Phase 2 Study Of IL-21 In Metastatic Melanoma Conducted By NCIC
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced that Interleukin 21 (IL-21) demonstrated an impressive overall response rate in the treatment of metastatic melanoma. In interim Phase 2 results from 24 patients, 29 percent showed a partial response, with an additional 33 percent of patients showing stable disease in this difficult to treat disease.
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HIV Antibody Tests Unreliable For Early Infections In Teens
A previously healthy teenager shows up at the doctor"s office with a sore throat, fever, aches and general malaise. Routine blood tests are normal, an HIV test comes back negative, and the pediatrician sends the patient home with a diagnosis of acute viral infection.
Oncology

What Is Exercise? The Benefits Of Exercise

When we talk about exercise, we nearly always refer to physical exercise. Exercise is the physical exertion of the body - making the body do a physical activity which results in a healthy or healthier level of physical fitness and both physical and mental health. In other words, exercise aims to maintain or enhance our physical fitness and general health. People exercise for many different reasons. Some of them are included below: *Strengthening muscles *Optimizing the cardiovascular system *Practicing specific athletic skills *Controlling bodyweight *For fun *To win *To socialize *To get away from it all People don"t exercise for various reasons. A study found that stress levels and cultural considerations affect how much and for what reasons college students exercise. There are three broad Intensities of exercise: *Light exercise The exerciser is able to talk while exercising. Going for a walk is an example of light exercise. *Moderate exercise The exerciser feels slightly out of breath during the session. Examples could be walking briskly, cycling moderately, or walking up a hill. *Vigorous exercise The exerciser is panting during the activity. The exerciser feels his/her body is being pushed much nearer its limit, compared to the other two intensities. This could include running, cycling fast, and heavy weight training. Read all the latest news on: Sports Medicine Obesity / Fitness / Weight Loss Exercise can be divided into three broad categories, aerobic, anaerobic, and agility training: Aerobic exercise Aerobic exercise has the aim of improving the body"s consumption of oxygen. The word aerobic means with oxygen. Aerobic refers to our body"s use of oxygen in its metabolic process (energy-generating process). Most aerobic exercises are done at moderate levels of intensity for longer periods, compared to other categories of exercise. An aerobic exercise session involves warming up, exercising for at least 20 minutes, and then cooling down. Aerobic exercise involves mainly the large muscle groups. A physical therapist, Col Pauline Potts, and an exercise physiologist, Kenneth Cooper M.D., both in the US Air Force, were the first to use the term aerobic exercise during the 1960s. Dr. Cooper wanted to find out why some very strong people were poor at long-distance running, swimming and cycling. He researched people"s performance in terms of their ability to use oxygen with the use of a bicycle ergometer. In 1968 Dr. Cooper published his book Aerobics. The book included scientific programs using aerobic exercises, such as swimming, running, cycling and walking. The book became a bestseller. All present aerobic programs use Cooper"s data as a baseline. Aerobic exercise is generally performed at a moderate level of intensity over a long period. Running for 20 minutes is an aerobic exercise, while sprinting 200 meters is not. Playing badminton for 30 minutes is an aerobic activity if the movements of the players are fairly continuous. Golf, on the other hand, is not seen as aerobic because the heart rate has not been raised at a sustained level for long enough. Aerobic exercise is considered to have the following benefits: *Strengthens the muscles that are involved in respiration - exercises that facilitate the flow of air in and out of the lungs. *Strengthens and enlarges the heart muscle. This improves aerobic conditioning - pumping of blood and the heart rate (lowers the pulse of a person when he/she is resting). *Tones muscles throughout most of the body. *Reduces blood pressure. *Improves circulation. *Raises the number of red blood cells, which in turn facilitates transportation of oxygen. *The sleep quality of insomnia patients can improve with moderate exercise, a study found. *Improves mental health. *A study found that exercise reduces migraine suffering. *Reduces the risk of heart disease and cardiovascular problems. *Helps improve survival rates of patients with cardiovascular diseases significantly, as this study found. *Stimulates bone growth (high impact aerobic exercise), reduces risk of osteoporosis. *Increases stamina or endurance. Aerobic activity increases the body"s ability to store energy molecules such as fats and carbohydrates within the muscle. *Increases blood flow through muscles. *Improves muscles" ability to use fats during exercise, thus preserving the intramuscular glycogen. What is Anaerobic exercise? The aim of anaerobic exercise is to build power, strength and muscle. The muscles are exercised at high intensity for short durations. A short duration usually means no more than about two minutes. Anaerobic means without air. Anaerobic exercises improve our muscle strength and our ability to move with quick bursts of speed. When thinking of anaerobic exercise, think of short and fast or short and intensive. Anaerobic exercises include: *Weight lifting *Sprinting *Intensive and fast skipping (with a rope) *Interval training *Isometrics *Any rapid burst of hard exercise Oxygen is not used for energy during anaerobic exercise. During this type of exercise a by-product - lactic acid - is produced. Lactic acid contributes to muscle fatigue and must be used up during recovery before that muscle can be subjected to another anaerobic session. During the recovery period oxygen is used to give the muscle a "refill" - to replenish the muscle"s energy that was used up during the intensive exercise. Overall, anaerobic exercise uses up fewer calories than aerobic exercise. The cardiovascular benefits of aerobic exercises are greater than the cardiovascular benefits of anaerobic exercises. However, anaerobic exercise is better at building strength and muscle mass, while still benefitting the heart and lungs. As you build more muscle you will burn more fat, even at rest. Muscles burn more calories per unit volume than any other tissue in the body. A muscly person burns more calories than a non-muscly person, even if while he/she is resting. This study found that resistance training may aid in weight loss. How Does Anaerobic Exercise Work? When a short, intensive burst of activity occurs there is a temporary shortage of oxygen being delivered to the working muscles at first. The production of anaerobic energy creates a by-product; lactic acid. As mentioned above, lactic acid causes muscle fatigue, which is the reason the session cannot last long. However, after regular training the person"s body becomes better equipped to handle lactic acid. After several practice sessions the body becomes better at getting rid of lactic acid - it also learns how to produce less of it. The body also produces buffers that postpone the onset of fatigue during an anaerobic session. Anaerobic exercises offer the following benefits: *The exerciser gets stronger *The exerciser experiences growth in muscle mass *Strengthens bones *Strengthens and protects the joints *Helps control bodyweight *The exerciser can withstand a greater buildup of lactic acid and other waste substances, and can eliminate them more rapidly What is agility training? Agility training aims to improve a person"s ability to speed up and slow down, change directions while maintaining balance and control. In tennis, for example, agility training helps the player maintain control over his/her court positioning through good recovery after each shot. A crucial skill in tennis is to be able to position yourself in the court so that you can hit the ball to maximum effect. Agility does not only help the tennis player get to the ball more effectively and set up for a better shot, it also gives him/her better balance in order to hit the ball. Agility training is practiced extensively by people who practice certain sports where positioning, coordination, balance and the ability to suddenly change posture and speeds are essential. Agility and coordination are two key attributes for a successful soccer (UK/Ireland: football) player. Such compound movements as dribbling, turning, passing and intercepting require a wide assortment of balance, coordination and other skills, such as the ability to accelerate and decelerate quickly. A good soccer player also needs excellent special awareness and accurate timing. Soccer players often practice improving their ability to change the direction of the body abruptly, or shift stance without losing balance. Agility includes speed, strength, balance and coordination. The following sports are known to require agility (there are many more than on this list): *Tennis *Soccer *Rugby *American football *Squash *Hockey *Badminton *Volleyball *Basket ball *Martial arts *Boxing *Wrestling Yoga and Pilates Some exercises include a combination of stretching, muscle strengthening, balance, etc. A good example is Yoga. Many experts say stretching is an exercise in itself. Yoga exercises, or movements, improve your balance, flexibility, posture and circulation. Yoga originated in India a long time ago, and is aimed at unifying the mind, body and spirit. Modern yoga - the type of yoga practiced by most people in western countries - uses a combination of meditation, posture, and breathing exercises. Yoga can be tailored to meet the needs of individuals, such as those with arthritis, asthma, or certain body pains. Pilates is similar to Yoga, but it focuses more on the core abdominal and back muscles. Some facts about exercise and lack of exercise Most of us know how beneficial exercise is for our health. It is surprising, however, how little many of us know about the dangers of being unfit. In Western Europe, North America, Japan, Australasia, and much of the rest of the world, the number of overweight/obese people is growing alarmingly fast. *The UK has a population of 61 million. 24 million of them are overweight/obese today. Experts say it will not be long before 25% of the UK"s population is obese (not overweight, just obese). The USA has already reached that

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