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Celebrity Performer Duo Receives MDA Directors' Awards
The Muscular Dystrophy Association has awarded its highest philanthropic achievement honor, the MDA Directors" Award, to two entertainment industry celebrities.
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Pennsylvania House Approves Bill Allowing Young Adults To Remain On Parents' Health Insurance Policies Up To Age 29
The Pennsylvania House last week voted to approve a bill that allows state residents up to age 29 to be added to or remain on their parents" health insurance plans as long as they live in the state or are full-time students, the Harrisburg Patriot-News reports. They also must be single and not have dependents.According to national data, young adults between ages 19 and 29 make up the largest segment of the U.S. population without health insurance. The Pennsylvania Insurance Department estimates that nearly 400,000 state residents in that age group are uninsured. The bill allows employers to decide if they want to offer the coverage option to their employees. Families choosing to add adult dependents to their health plans will have higher premiums. Gov. Ed Rendell (D) is expected to sign the bill, which the state Senate approved in March (Thompson, Harrisburg Patriot-News, 5/14). Prescription for Pennsylvania Plan
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Some Small Businesses Must Cut Employee Health Benefits Or Lay Off Workers Amid Economic Recession
Small businesses increasingly are eliminating their employee health coverage plans because of rising health care premiums and declining revenue attributed to the current economic recession, the Wall Street Journal reports. About 10% of small companies are considering ending their employee health coverage plans over the next year, compared with 3% of small businesses in 2005, according to a recent survey by the National Small Business Association. In 2008, 38% of small companies offered health coverage, compared with 41% in 2007 and 61% in 1993, according to NSBA. According to a Hewitt Associates survey, 19% of all U.S. businesses plan to halt providing health care benefits to their employees in the next three to five years.A rise in health care coverage premiums has contributed to employers eliminating plans, according to the Journal. Premiums for single policies increased by 74% for small businesses from 2001 to 2008, according to the Kaiser Family Foundation. According to Scott Krienke, senior vice president of product lines for Assurant Health, health insurance premiums for small businesses increase by 8% to 16% annually on average, with smaller firms often having the highest increases. According to the Journal, many employers are choosing to eliminate health coverage instead of eliminating jobs or closing down their business. Some businesses have chosen instead to shift more health care costs to workers, change health insurers, switch prescription drug plans to encourage employees to purchase more generic drugs or offer employees wellness plans that encourage healthy habits as a strategy to reduce health care costs, the Journal reports (Mattioli, Wall Street Journal, 5/26).
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Tummy Troubles -- Gastrin Key In Bacterial-Induced Stomach Cancer

Current research suggests that levels of gastrin play a key role in the development of Helicobacter-induced stomach cancer. The related report by Takaishi et al, "Gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice," appears in the July 2009 issue of The American Journal of Pathology. More than 50% of the world"s population is infected with Helicobacter pylori, which causes chronic inflammation of the stomach lining and is strongly linked to the development of gastric ulcers and stomach cancer. Stomach cancer is the second leading cause of cancer-related deaths world-wide. Helicobacter infection results in increased expression of gastrin, a hormone that stimulates secretion of gastric acid; however, the role of gastrin in cancer development remains unclear. High levels of gastrin lead to the development of stomach cancer, but absence of gastrin has been shown to increase the numbers of tumors in the gastric antrum, the lower section of the stomach that empties into the small intestine. To reconcile this apparent disparity, a group led by Dr. Timothy Wang at the Columbia University Medical Center in New York, NY examined the contribution of Helicobacter infection to gastric cancer in animal models with either high expression of gastrin or no gastrin at all. They found that Helicobacter infection in mice with high levels of gastrin resulted in cancer of the gastric corpus (main body of the stomach), whereas infection in gastrin-deficient mice developed cancer in a different part of the stomach, the gastric antrum. Gastrin, therefore, plays a key role in the development of Helicobacter-induced stomach cancer, but may have distinct effects on carcinogenesis in different parts of the stomach. Takaishi et al suggest that "gastrin may serve as a rheostat for the stomach. Gastrin likely plays a central role in the safety network for the protection from mucosal damages caused by gastric acid secretion induced by gastrin itself, and thus either too much or too little gastrin can predispose to carcinogenesis. Therefore, clinicians in the future may need to be more circumspect when prescribing with acid suppressive drugs, such as proton-pump inhibitors, for a long-term use in patients infected with Helicobacter pylori." In future studies, Dr. Wang and colleagues plan to study "host factors other than gastrin [that] are also ò€¦ important for Helicobacter-associated gastric carcinogenesis. These include specific cytokines and chemokines induced by Helicobacter infection, and modulated by gastrin, that link inflammation and cancer. In addition, they plan to study the role of other non-Helicobacter bacteria that colonize the stomach when acid secretion is suppressed, since bacterial overgrowth likely contributes to gastric carcinogenesis". This work was supported by grants from the National Institutes of Health, the Medical Research Council, the Welcome Trust and the Wolfson Foundation. Takaishi S, Tu S, Dubeykovskaya ZA, Whary MT, Muthupalani S, Rickman BH, Rogers AB, Lertkowit N, Varro A, Fox JG, Wang TC: Gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice. Am J Pathol 2009 175: 2775-2786 Angela Colmone American Journal of Pathology


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