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New Study Helps Explain Why It Is Easy To Encode New Memories But Hard To Hold Onto Them
Memories aren"t made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biology, Rex et al. reveal that LTP"s actin reorganization occurs in two stages that are controlled by different pathways, a discovery that helps explain why it is easy to encode new memories but hard to hold onto them.
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GOP State Sens. Ask Bayh, Lugar To Oppose DOJ Nominee Johnsen; Senate Confirms FDA Head Hamburg
In a May 15 letter to Sens. Evan Bayh (D-Ind.) and Dick Lugar (R-Ind.), 31 Republican Indiana state senators asked the lawmakers to oppose the confirmation of Indiana University law professor Dawn Johnsen, President Obama"s nominee to head the Office of Legal Counsel in the Justice Department, due to her support for abortion rights, the AP/Milwaukee Journal Sentinel reports. The state senators wrote that Johnsen"s support for abortion rights "is more than simply pro-choice" and that "she is pro-choice in an extremely radical way," citing Johnsen"s statements and writings. The letter, which was signed by all but two of the state"s Republican senators, asked Bayh and Lugar to consider what Johnsen"s nomination "could mean for the future of the country." Indiana Senate President Pro Tem David Long (R) said, "It"s a statement from a very strong pro-life caucus," adding, "It is not based on the fact she is pro-choice, it is based on the fact that she is radically so." According to Long, the letter originated with a request from Indiana Right to Life to urge Bayh and Lugar to oppose Johnsen"s confirmation.Johnsen in an e-mail said that as a nominee she would not make public comments to the media. White House spokesperson Amy Brundage said that Johnsen "will bring unquestioned integrity and a commitment to non-partisan interpretation of the law to the Office of Legal Counsel, and we"re pleased that both of Indiana"s senators have expressed support for her nomination." Lugar spokesperson Andy Fisher on Monday in an e-mail said that although the senator has said he would not oppose Johnsen"s confirmation, Senate Democrats currently do not have enough support to move forward with the confirmation process. Bayh supports Johnsen"s confirmation, according to Bayh spokesperson Eric Kleiman (Smith, AP/Milwaukee Journal Sentinel, 5/18).Senate Confirms Hamburg as FDA CommissionerThe Senate on Monday by voice vote confirmed the nomination of Margaret Hamburg to be FDA commissioner, CQ HealthBeat reports (CQ HealthBeat, 5/18). According to the AP/Washington Post, Hamburg"s priorities include leading the development of a swine flu vaccine and overhauling the U.S. food safety system. During her confirmation hearing, Hamburg, a bioterrorism expert, said that she wants to increase consumer confidence in the agency by increasing transparency and accountability. Previously, Hamburg served as an assistant health secretary under President Clinton (AP/Washington Post, 5/19).
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Stem Cell Discovery May Bring Tissue Repair Closer
The goal of creating adult blood stem cells from human embryos to prepare a patient for tissue and organ transplant has been brought a step closer by research carried out at the MRC Molecular Haematology Unit at Oxford University.
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The Therapeutic Process Of Mother-Infant Psychotherapy

Psychotherapists who treat mothers suffering from postpartum depression and other mood disorders with their infants have developed a proven process that contributes to a greater positive experience with immediate insights for the mothers to develop healthy connections between their maternal experiences and their infants" behaviors. Given the documented detrimental effects of postpartum depression on infants and the mother-infant relationship, mental health professionals concerned with child development and families are anxious to understand models of best practices in order to prevent untoward outcomes. In a focus group study to evaluate the effectiveness of an agency-based mother-infant treatment program, nine therapists, each with 20 + years experience working with parents and babies, talked about their practices. A Boston University School of Social Work-led research team asked the participants to summarize their work, then describe what makes for therapeutic change in mother-infant therapy and how they know when it"s effective. Their findings "Mother-Infant Psychotherapy: Examining the Therapeutic Process of Change," were just published in Infant Mental Health Journal. The therapists -- a multidisciplinary group of three psychologists, four social workers, one psychiatrist and an educator -- elaborated on how they helped depressed mothers tune in to the nuances of what their babies were telling them and communicated how best to respond. The clinicians are part of the Jewish Family and Children"s Service Early Connections program, a home-based mother-infant psychotherapy intervention that specializes in the treatment of postpartum depression (PPD) and mood disorders. The program"s key goal is to increase the mother"s ability to be affectively present in her interaction with the child and to address issues that arise as result of becoming a mother. "Unlike other psychotherapies, the presence and contribution of the infant are unique to mother-infant treatment and act to catalyze change throughout the therapeutic process. Observing and attending to the infant"s actions and communicative signals in the here and now of the session offer the therapist the opportunity to create connections between maternal experience and infant behavior," the study noted. In examining what happens during these session and what makes it therapeutic, the clinicians cited a great deal of unpredictability, boundary fluidity and questions about role definition - experiences not found in mother-only office visits. Recognizing the mother"s specific experiences or capacities, or interactions with her infant was central to the therapeutic change. For these therapists, working in the home of the client presents both challenges and opportunities, ranging from the unpredictable nature of moment-to-moment life with a baby to the clinician"s role. The researchers, led by Ruth Paris, Assistant Professor of Clinical Practice at the BU School of Social Work, also analyzed the discussion among members of the focus group when one therapist cited a "now moment," in a mother-infant treatment session where the therapist was playing with the infant under the watchful eye of the mother. When the therapist said she was tired and told the infant she was putting her down, her actions surprised the mother. "ň€¦because something she had been struggling with was that she had to be a perfect mother, and she couldn"t let her baby down, she couldn"t kind of disappoint the baby, she had to be there 100% and there I was, kind of, in this alive moment setting a limit with the baby and disappointing the baby in some way." This "now moment" in which the both the client and the therapist hit upon something of significance, marks an increase in mutual therapist-client understanding. This clinical vignette also becomes a building block of therapeutic change and authentic relational development occurs, the study notes, "All the "now moments " are important to the treatment because there needs to be both a recognition and an understanding for these women who are very depressed to tune into their babies and see the communication," said Paris. "We are just beginning to understand the ways these experienced clinicians respond to mothers for optimal parenting and child welfare. The focus group provides a way for clinicians to get to a deeper place and develop their thinking with each other." In analyzing the clinicians" description of their approaches to families and how they viewed the relationships between themselves and the client mothers, the study concluded that there were seven overlapping concepts to understanding the therapeutic process. All of them are interwoven in any particular clinical encounter and also serve as guidelines for ways clinicians can facilitate the therapeutic process. They are: * Narration of the experience * Processing the experience * Connecting past and present * Modeling something new within the baby * Promoting new affective experiences * Opening future possibilities * Building reflective function. "Training new clinicians in mother-infant work includes, for example, prioritizing the clinical focus on the development of a relationship between clinician and mother that allows room for observation and reflection," the study concluded. "Furthermore, everyday moments among mother, baby and clinician offer powerful opportunities for problematic dynamics to develop for new interactive possibilities to emerge. Clinicians need to be open and attuned to small unplanned moments of interaction as potential arenas for therapeutic action." In addition to Ruth Paris the other authors are Eda Spielman, clinical director of the Center for Early Relationship Support at Jewish Family and Children"s Service of Greater Boston and Rendelle E. Bolton, a graduate student at the BU School of Social Work. Ronald Rosenberg Boston University Medical Center


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