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Intraoperative Radioguidance With A Portable Gamma Camera: New Technique For Laparoscopic Sentinel Node Localisation In Urological Malignancies
UroToday.com - Our first results of sentinel node mapping with intraoperative radioguidance in urological tumors are described in our abstract. We selected this movie to show the whole imaging procedure. In a patient with prostate cancer, the radiopharmaceutical is injected in 4 depots into the prostate. After tracer administration, planar lymphoscintigraphy is performed after 15 minutes and in 2 hours is followed by a SPECT/CT. After fusion of corresponding SPECT and CT slices, the two-dimensional fusion images show the location of the sentinel nodes.
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Researchers Pinpoint A New Enemy For Tumor Suppressor P53
Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.
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Common ECG Finding May Indicate Serious Cardiac Problems
A common electrocardiogram (ECG) finding that has largely been considered insignificant may actually signal an increased risk of atrial fibrillation (a chronic heart rhythm disturbance), the future need for a permanent pacemaker and an increased risk for premature death. In their report in the June 24 Journal of the American Medical Association, researchers from Massachusetts General Hospital (MGH) and Boston University School of Medicine describe results of the first large-scale study looking at the significance of a prolonged PR interval in a general population.
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The Necessity Of Adrenalectomy At The Time Of Radical Nephrectomy: A Systematic Review

UroToday.com - To take the adrenal or not at the time of radical nephrectomy, that is the question. These researchers from New York University School of Medicine performed an extensive literature search to determine the role of adrenalectomy at radical nephrectomy and discovered that the incidence of solitary, synchronous, ipsilateral adrenal involvement, and therefore potentially curable tumor disease with ipsilateral adrenalectomy occurred extremely infrequently - in only 1% to 5% of cases. Cross sectional imaging is now accurate at demonstrating the absence of adrenal involvement but still carries a significant risk of false positives. Disease-specific and overall survival of those patients undergoing radial nephrectomy, with or without adrenalectomy, is very similar. However, several characteristics on preoperative evaluation are associated with a greater risk of adrenal tumor involvement and these include both upper pole location of the renal tumor and size > 7 cm, multi-focality of the disease, venous thrombosis particularly at the level of the adrenal vein, and CT or MRI adrenal abnormality such as non-visualization, irregular borders, nodule, enlargement or contiguous infiltration. Therefore it would appear that in the majority of patients, the apparent benefit of ipsilateral adrenalectomy does not support it as a standard practice in all patients who have otherwise normal imaging preoperatively. However in the 2% of patients who have isolated adrenal metastasis, the concomitant adrenalectomy may provide a survival advantage. O"Malley RL, Godoy G, Kanofsky JA, Taneja SS J Urol. 2009 May;181(5):2009-17. doi:10.1016/j.juro.2009.01.018 Written by UroToday.com Contributing Editor Elspeth M. McDougall, MD, FRCSC, MHPE UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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