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Editorial, Opinion Piece Discuss Issues Related To Routine HIV Testing
A recent directive to streamline the HIV testing consent process in Massachusetts as well as consent forms "no longer hav[ing] to accompany test specimens to the lab," are bringing "the state closer to a CDC recommendation that clinicians provide HIV screening on an opt-out basis," according to a Boston Globe editorial. "The opt-out provision is at the heart" of legislation sponsored by state Sen. Patricia Jehlen (D) that would end the state"s requirement of written consent for HIV testing "and instead have healthcare providers inform patients verbally that the test is planned but that they can decline it," the editorial states, adding, "The Jehlen bill would help destigmatize HIV testing itself" (7/6).
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American Chemical Society Praises Nomination Of Collins As National Institutes Of Health Director
The President of the American Chemical Society, Thomas H. Lane, Ph.D., issued the following statement on President Obama"s nomination of Francis Collins, M.D., Ph.D., to be Director of the National Institutes of Health (NIH):
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FDA Classifies Medtronic Voluntary February Recall For Intrepid™ Intervertebral Body Fusion Device As Class II
Medtronic, Inc. (NYSE: MDT) announced that the U.S. Food and Drug Administration (FDA) has classified its voluntary recall action of the Intrepid™ Intervertebral Body Fusion Device as a Class II recall. Medtronic initiated a voluntary recall of the product on February 6, 2009, and communicated the risk to physicians and hospitals. As of the date of this news release, all unused product has been retrieved and Medtronic has received confirmation of notification from all affected physicians and hospitals.
Mental Health

Stem Cell Discovery May Bring Tissue Repair Closer

The goal of creating adult blood stem cells from human embryos to prepare a patient for tissue and organ transplant has been brought a step closer by research carried out at the MRC Molecular Haematology Unit at Oxford University. Blood, or haematopoietic, stem cells (HSCs), are a type of adult stem cell that can produce several different types of blood cell, including those of the immune system that are involved in tissue rejection. Scientists have so far been unable to generate HSCs from embryonic stem cells, largely because they have not known how the embryo makes these cells. By studying zebrafish embryos, the research team found BMP4, a protein involved in bone and cartilage development, to be the critical signal required to generate HSCs in the dorsal aorta, which is the chief artery that arises from the heart to distribute blood to the body. Lead author Professor Roger Patient, from the MRC Molecular Haematology Unit, said: "The ability to make adult stem cells from embryonic stem cells would obviously benefit regenerative medicine because one of the characteristics of adult stem cells is that they are present in very small numbers and are resistant to expansion. "There is substantial evidence for conservation of genetic mechanisms among vertebrates. Human embryos for example have been shown to express BMP4 under the dorsal aorta as seen in zebrafish. Zebrafish provide a large number of externally developing, and therefore manipulable, embryos that are transparent, allowing developmental processes to be observed in great detail." One of the benefits, in the specific case of HSCs, is the potential for preparation of patients for transplantation. Another benefit is that numbers are always limited, even from bone marrow or umbilical cord. Therefore an alternative, potentially limitless could be of great clinical benefit. Notes - This paper, Hedgehog and Bmp Polarize Hematopoietic Stem Cell Emergence in the Zebrafish Dorsal Aorta, is in the June edition of Developmental Cell. - Other centres involved in the research included Department of Chemistry, Chemistry Research Laboratory; Department of Pharmacology, Oxford University; Institute of Genetics, Queens Medical Centre, Nottingham University; Department of Biochemistry, Washington University; Centre for Developmental and Biomedical Genetics, Sheffield University. Medical Research Council


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