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MiR-196a Promotes The Metastases Of Tumors
MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of the human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination. miR-196a increased the chemosensitivity towards platin derivatives such as cisplatin and oxaliplatin and might be a useful biomarker.
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Association of American Medical Colleges Supports Hospital Agreement On Health Care Reform
AAMC (Association of American Medical Colleges) President and CEO Darrell G. Kirch, M.D., issued the following statement on the agreement reached by the hospital community, the Obama administration, and the Senate Finance Committee in support of health care reform:
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Needle Exchange Program In Humboldt County, Calif., Forced To End; Officials Hoping For Federal Help
Health officials in Humboldt County, Calif., "will be watching closely" the debate expected to ensue over legislation introduced last week containing "a provision that would scrap the federal funding ban on needle exchange programs that has been in place for years," the Eureka Times-Standard reports. According to the Times-Standard, "This month, Open Door Community Health Centers" clinics in Arcata and Eureka quietly stopped administering the needle exchange program they have operated for almost a decade." Open Door Community Health Centers Chief Operating Officer Cheyenne Spetzler, said, "The footprint of the program just kept getting bigger." In addition, grant funding was often limited to covering the costs of the needles and not the costs of administering the programs, Spetzler said. County Department of Health and Human Services Programs Director Barbara LaHaie said the county is currently seeking alternatives to continue the program. However, "Without a reliable funding stream, that may prove difficult," the article states (Greenson, 7/13).
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Role Of Liver Transplantation Techniques In Surgical Management Of Advanced Renal Urothelial Carcinoma With/without Inferior Vena Cava Thrombus

UroToday.com - Large urothelial carcinoma of the renal pelvis poses a diagnostic as well as surgical challenge to the urologist. This type of malignancy is frequently mistaken preoperatively for renal cell cancer due to its low incidence (10% of all renal malignancies) especially when associated with tumor extension into the inferior vena cava. The presence of a large renal mass should therefore not dissuade the urologist to perform cystoscopy and cytology in order to complete hematuria work-up. Opening the specimen in the operating room will provide clues for the origin of the tumor. The surgical management of large urothelial carcinoma of the renal pelvis is radical nephro-ureterectomy, which may be considerably impeded by major desmoplastic reaction and rich collateralization. Particularly in cases of inferior vena cava involvement liver mobilization is required to achieve complete tumor resection. The department of urology and division of transplantation surgery at University of Miami Miller School of Medicine have collaborated for over 10 years on cases of renal tumors where liver mobilization and inferior vena cava exploration is anticipated. Dr. Gaetano Ciancio bridges the two specialties having completed a urology residency and transplant fellowship at University of Miami. His unique interface allowed the use of liver transplantation techniques for the resection of large renal tumors with or without inferior vena cava involvement. While operative times (mean 7.5 hours) and blood loss (mean 1.5 L) were significant in our series, the tumor could be completely and safely resected in all patients. Nevertheless, mean postoperative survival was only 6 months secondary to disease recurrence. Neoadjuvant chemotherapy may significantly improve survival in such patients as shown previously for muscle-invasive urothelial carcinoma of the bladder, however, it relies on accurate preoperative diagnosis. A prospective clinical trial is needed to evaluate the impact of neoadjuvant chemotherapy on respectability and disease-specific survival. Written by Wolfgang H. Cerwinka, MD1, Murugesan Manoharan, MD, Mark S. Soloway, MD, and Gaetano Ciancio, MD as part of Beyond the Abstract on UroToday.com. UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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