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Enzyme Necessary For DNA Synthesis Can Also Erase DNA
In this week"s edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bacteria. The findings advance our knowledge of how DNA content has been reduced, which is something that has occurred in bacteria that live as parasites inside the cells of other organisms.
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New Clinical Data For Tesetaxel, A Leading Oral Taxane, Show Anticancer Activity And Acceptable Safety In Ongoing Study
Genta Incorporated (OTCBB: GNTA.OB) announced preliminary results from its ongoing clinical study of tesetaxel, a leading oral taxane in the Company"s investigational drug portfolio. The new data show a favorable safety profile with a low incidence of serious adverse events, along with objective responses that have been observed at less than the maximally tolerated dose (MTD). The data are featured in a presentation today at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, FL.
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Drop In Access To Abortion Would Reward Antiabortion-Rights Violence, Opinion Piece Says
After the murder last month of Kansas abortion provider George Tiller, "there is a very real danger" that the availability of abortion later in pregnancy "will end in this country -- not after public deliberation, legislative debate and majority vote, but because antiabortion absolutists on the fringe have intimidated and blacklisted doctors and successfully threatened violence against them," Jim Buie, author of the blog The Buie Knife, writes in a Newsweek.com opinion piece. Buie writes that his parents in the early 1950s chose to institutionalize his three-year-old-brother, who was born with severe Down syndrome, after their attempts to care for him left them with "severe emotional distress" and unable "to meet the needs of their healthy children."Buie continues that he "cannot say that the option of a late-term abortion would have been the right one for my parents." However, "some of the arguments advanced by pro-life forces disturb me," he says, especially a "tendency to romanticize, sentimentalize and idealize life with a cute, forever-young Down-syndrome "angel child."" Buie adds, "It"s an argument I find off-putting, especially when it"s espoused by people who have never been through the wringer trying to care for a child whose disability level is on the most severe end of the scale." He continues, "At the same time, it is very disturbing that until recently, the majority of Down-syndrome fetuses were aborted without expectant mothers receiving proper information or support."Because of Tiller"s murder, it is "possible there won"t be any doctors in the country willing to perform" abortion later in pregnancy, "even if prenatal tests indicate severe retardation," according to Buie, who adds that this would mean that "domestic terrorism could win." He concludes, "It would mean that parents like my own would no longer have a choice, and would instead be forced to endure the same harsh realities that were present in the 1950s" (Buie, Newsweek.com, 6/17).
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New UK Drive To End Malaria Deaths

An additional 30 million bed nets, the development of life-saving new treatments and new funding to increase access to anti-malarial drugs are announced today in a package of measures by International Development Secretary, Douglas Alexander, as the UK continues its fight to rid the world of malaria. Every year 247 million people are infected with malaria with nearly one million of those dying from the disease. The Department for International Development (DFID) has led the UK"s programme to tackle malaria. By 2010 we will have met the Prime Minster"s pledge to deliver 20 million bednets- preventing some 110,000 child deaths and our funding to the Global Fund has helped deliver 74 million malaria treatments. Today Douglas Alexander announced the action DFID will take over the coming years, which will prevent millions of people dying from this preventable disease. These measures include: - 30 million new long lasting insecticide treated bednets (10 million each year from 2010 to 2013), to help ensure all women and children that need to are sleeping under a bednet and to help replace existing bednets where required. This new commitment will help prevent a further 165,000 child deaths. - ÷£19 million from 2010 to the Medicines for Malaria Venture to support the development of new drugs to combat malaria, including those to treat children. - Financial support for the Affordable Medicines Facility for Malaria (AMFM) pilot which makes the newer, effective malaria combination therapies available at low prices to public and private sectors by negotiating directly with drug suppliers to secure lower prices for guaranteed orders. This means they can be passed on to patients at low prices or for free. DFID is currently providing ÷£40 million over two years and beyond 2010 we will maintain at least this level of support for the roll out and expansion of the AMFM, if it proves successful. - Exploring an Advanced Market Commitment (AMC) to create a range of vaccines by the end of 2009, including a special focus on malaria. AMC is an innovative financing scheme which works by using donor advance commitments to subsidise the purchase of effective vaccines desperately needed in the developing world- thereby creating commercial demand for the vaccines. DFID will stand ready to commit significant financial support to put in place a new AMC if the assessment study recommends we do so. - Driving and supporting action to encourage political leadership, commitment and public awareness about malaria with the goal of reaching the Global Malaria Action Plan target of reducing deaths to near zero by 2015. We will work closely with campaigns such as United Against Malaria - including Malaria No More - and use the 2010 World Cup as a way of raising awareness and support. International Development Secretary, Douglas Alexander, said: "It is shocking and wrong that one million people still die from malaria every year. Most of these lives could be saved if people slept under a bednet but all too often families cannot afford one. "That is why this Government is supplying families across Africa with bednets to protect them from this killer disease We are already committed to distributing 20 million bednets worldwide by 2010 and we are now aiming to supply a further 30 million nets by 2013. "Thanks to Britain we are saving millions of lives, which is something we can all be proud of." Department for International Development


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