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Advance Toward New Drugs That Turn Genes On And Off
Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of other disorders. Acting like an "on-off switch," the medications might ratchet up the production of proteins in genes working at abnormally low levels or shut off genes producing an abnormal protein linked to disease. Their report is in the current issue of ACS Chemical Biology, a monthly journal.
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Physicians Can Lead Health Care Reform Through Payment And Delivery System Reforms
Physicians can and should play a leading role in achieving health care reform by working towards comprehensive reform of the way health care is paid for and delivered, helping achieve a guaranteed 1.5 percent annual savings in health care costs that would pay for covering all Americans, according to a New England Journal of Medicine Perspective piece published online.
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Drug Manufacturer Receives Fast Track Designation From FDA
Pharmaceutical firm Biogen Idec announced that the American drug watchdog the Food and Drug Administration (FDA) has granted Fast Track designation for its multiple sclerosis (MS) drug PEGylated interferon beta-1a (BIIB017).
Oncology

New Technology At Great Ormond Street Hospital Is Aiding Faster Emergency Referrals To Its Specialist Paediatricians, England

Thanks to the introduction of an innovative IT system at the Children"s Acute Transport Service (CATS) hosted at Great Ormond Street Hospital for Children NHS Trust (GOSH), referring hospitals can now share perfect quality medical data on emergency patients more quickly and securely than ever before. The product, named CATS-i, has been co-developed by software manufacturer Cimar UK and GOSH. Over the last 12 months, the technology has been trialled by the CATS team at GOSH. CATS is a paediatric intensive care retrieval service for the North Thames and East Anglia region. The team provides telephone advice and sends a specialist team to safely bring sick children back to the intensive care unit at GOSH and other tertiary centres. More than 50 hospitals in and around London regularly refer patients to the service. Dr Padmanabhan Ramnarayan, consultant for the CATS team at GOSH and a co-inventor of CATS-i explains. "Previously, we simply relied on telephone conversations with referring clinicians and relatively low quality radiology (X-rays, CT scans) to make a quick assessment about a diagnosis. Radiology data would often be sent via courier, which loses us valuable time. In an emergency situation, every second counts and this is where CATS-i offers us a clear advantage. For example, in a recent case, a boy had been in a road traffic accident outside London and with the help of CATS-i we quickly determined from his medical data that he had a windpipe injury. The child was brought to GOSH by helicopter and was given life-saving treatment by our tracheal team." CATS-i offers a unique web-transmission service which allows pristine medical images to be transmitted from any hospital in the UK to remote recipients anywhere, securely, reliably and fast via an internet browser. The images are losslessly compressed (i.e. retaining absolute image quality), secure and encrypted throughout, so patient data confidentiality is not compromised. The user cannot send anything until they have a secure token issued by the CATS office each time. The CATS-i project was commended in NHS Innovations London"s Innovator Awards 2008. NHS Innovations London has recently brokered an agreement between GOSH and Cimar UK to distribute the co developed service. Dr Ramnarayan continues: "We"re very excited about this product being available commercially. It"s satisfying to see something that we"ve worked so hard on being made available to others so that they can improve the service to their patients". A prime-time BBC 1 series following the work of the CATS team is due to be screened later this year. NHS Innovations London


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