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Intraoperative Radioguidance With A Portable Gamma Camera: New Technique For Laparoscopic Sentinel Node Localisation In Urological Malignancies
UroToday.com - Our first results of sentinel node mapping with intraoperative radioguidance in urological tumors are described in our abstract. We selected this movie to show the whole imaging procedure. In a patient with prostate cancer, the radiopharmaceutical is injected in 4 depots into the prostate. After tracer administration, planar lymphoscintigraphy is performed after 15 minutes and in 2 hours is followed by a SPECT/CT. After fusion of corresponding SPECT and CT slices, the two-dimensional fusion images show the location of the sentinel nodes.
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Adopting Low-Risk Dietary And Lifestyle Factors Related To Lower Incidence Of High Blood Pressure
Adherence to modifiable lifestyle and dietary factors including maintaining normal weight, daily vigorous exercise, eating a diet high in fruits, vegetables, low-fat dairy products and low in sodium and taking a folic acid supplement was associated with a significantly lower incidence of self-reported hypertension among women, according to a study in the July 22/29 issue of JAMA.
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Report On Contaminated Drinking Water At Camp Lejeune
Two chemicals - trichloroethylene (TCE) and tetrachloroethylene (PCE) - found to have contaminated drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1985 have been linked to certain diseases and disorders, including various cancers. A new report from the National Research Council, Contaminated Water Supplies at Camp Lejeune - Assessing Potential Health Effects, reviews scientific evidence about the potential adverse health effects that could occur after exposure to TCE, PCE, and other contaminants; recommends the usefulness of conducting additional studies on former residents of the base; and identifies scientific considerations that could help the U.S. Department of the Navy, under which the Marine Corps operates, set priorities on future actions. The report will be released at a 90-minute public briefing.
Mental Health

New Mechanism For Amyloid Beta Protein's Toxic Impact On The Alzheimer's Brain

Scientists have uncovered a novel mechanism linking soluble amyloid í² protein with the synaptic injury and memory loss associated with Alzheimer"s disease (AD). The research, published by Cell Press in the June 25 issue of the journal Neuron, provides critical new insight into disease pathogenesis and reveals signaling molecules that may serve as potential additional therapeutic targets for AD. Amyloid í² protein (Aí²) plays a major pathogenic role in AD, a devastating neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. "Given the mounting evidence that small soluble Aí² assemblies mediate synaptic impairment in AD, elucidating the precise molecular pathways by which this occurs has important implications for treating and preventing the disease," explains senior study author, Dr. Dennis Selkoe from the Center for Neurologic Diseases at Brigham and Women"s Hospital and Harvard Medical School. Dr. Selkoe, Dr. Shaomin Li, and colleagues examined regulation of a cellular communication phenomenon known as long-term synaptic depression (LTD). LTD has been linked with neuronal degeneration, but a role for Aí² in the regulation of LTD has not been clearly described. The researchers found that soluble Aí² facilitated LTD in the hippocampus, a region of the brain intimately associated with memory. The enhanced synaptic depression induced by soluble Aí² was mediated through a decrease in glutamate recycling at hippocampal synapses. Excess glutamate, the major excitatory neurotransmitter in the brain, is thought to contribute to the progressive neuronal loss characteristic of AD. The researchers went on to show that Aí²-enhanced LTD was mediated by glutamate receptor activity and that the LTD could be prevented by an extracellular glutamate scavenger system. A very similar enhancement of LTD could be induced by a pharmacological blocker of glutamate reuptake. Importantly, soluble Aí² directly and significantly decreased glutamate uptake by isolated synapses. "Our findings provide evidence that soluble Aí² from several s enhances synaptic depression through a novel mechanism involving altered glutamate uptake at hippocampal synapses," concludes Dr. Selkoe. "These results have both mechanistic and therapeutic implications for the initiation of hippocampal synaptic failure in AD and in more subtle forms of age-related Aí² accumulation." Future studies are needed to determine precisely how soluble Aí² protein physically interferes with glutamate transporters at the synapse. The researchers include Shaomin Li, Brigham and Women"s Hospital, Harvard Medical School, Boston, MA; Soyon Hong, Brigham and Women"s Hospital, Harvard Medical School, Boston, MA; Nina E. Shepardson, Brigham and Women"s Hospital, Harvard Medical School, Boston, MA; Dominic M. Walsh, University College Dublin, Dublin, Ireland; Ganesh M. Shankar, Brigham and Women"s Hospital, Harvard Medical School, Boston, MA; and Dennis Selkoe, Brigham and Women"s Hospital, Harvard Medical School, Boston, MA. Cathleen Genova Cell Press


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