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CHMP Recommends 'Januvia(R)'(sitagliptin), From MSD, For Restricted First Line Use In European Union
Merck & Co., Inc. (Whitehouse Station, N.J., U.S.A.), which operates in many countries as Merck Sharp & Dohme (MSD), has received a positive opinion from the European Medicines Agency"s (EMEA) Committee for Medicinal Products for Human Use (CHMP) recommending restricted first line use of "Januvia" (sitagliptin) for the treatment of type 2 diabetes. With this positive opinion, the CHMP recommends that sitagliptin be indicated to improve glycaemic control when diet and exercise alone do not provide adequate glycaemic control and when metformin is inappropriate due to contraindications or intolerance. If this opinion is accepted by the European Commission, sitagliptin will be the only diabetes treatment in the DPP-4 inhibitor class to have a restricted first line indication.
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Opinion Pieces React To Obama's Nomination Of Sotomayor To Supreme Court
Several newspapers on Wednesday included editorials and opinion pieces on President Obama"s nomination of Judge Sonia Sotomayor to the Supreme Court. Summaries appear below. ~New York Times: Obama "seems to have made an inspired choice" in selecting Sotomayor as his nominee because she "has an impressive judicial record, a stellar academic background and a compelling life story," a Times editorial states. According to the editorial, "Based on what we know now, the Senate should confirm her so she can join the court when it begins its new term in October." The editorial notes that, "Conservative activists have already begun trying to paint Judge Sotomayor as a liberal ideologue, but her carefully reasoned, fact-based decisions indicate otherwise." The editorial continues, "If Judge Sotomayor joins the court, it will be a special point of pride for Hispanic-Americans," and "will also bring the paltry number of female justices back to two." It adds, "Judge Sotomayor, though, is more than just a distinguished member of two underrepresented groups. She is an accomplished lawyer and judge, who could become an extraordinary Supreme Court Justice" (New York Times, 5/27).~Gerard Magliocca, New York Times: In addition to sharing Obama"s "experience and intellect," Sotomayor "also mirror"s the president"s measured temperament," Magliocca, a law professor at Indiana University, writes in a Times opinion piece. Magliocca writes that he has known Sotomayor for 13 years and notes that although he is a conservative and has at times been "at odds with" Sotomayor professionally, he does not dispute her qualifications. According to Magliocca, "For those of us who think that intellectual rigor and fairness are the crucial factors" to be a Supreme Court justice, "no matter which party the president hails from, there is no question that Judge Sotomayor should be confirmed" (Magliocca, New York Times, 5/27).~USA Today: Upon hearing that Sotomayor was Obama"s nominee, Republican critics "quickly insisted that the Senate assure itself that Sotomayor would not make rulings based on her "personal politics, feelings and preferences,"" a USA Today editorial states. According to the editorial, "To some extent, the entire argument is overblown. People inevitably are the product of their experiences, and they can hardly shed their history and character at the courthouse door." The editorial continues, "That is why the court is enriched by having an eclectic mix of justices who can bring differing perspectives to bear on the case at hand." The editorial concludes, "Sotomayor"s education and experience make her far more than a political twofer who allowed Obama to check the "female" and "Hispanic" boxes. But there"s a limit to the application of empathy and heritage to the law, and her confirmation hearings will be an opportunity for her to spell out exactly where she believes that line falls," (USA Today, 5/27).~ Steven Waldman, Wall Street Journal: "Everyone seems to assume" that Supreme Court nominee Sonia Sotomayor is "ardently for abortion rights," but there is "stunningly little information about her abortion views -- and what we do know hardly paints her as a pro-choice activist," Waldman, president and editor-in-chief of Beliefnet.com and author of "Founding Faith," writes in a Journal opinion piece. He continues that Sotomayor has ruled only on three cases "indirectly related to abortion," and each time ruled in a way preferred by abortion-rights opponents, "albeit for reasons unrelated to the merits of abortion." Although Sotomayor"s decisions in the cases were related "to matters of constitutional law and criminal procedure, ... at a minimum, it showed that whatever her abortion views, it didn"t produce some powerful inclination against the pro-life position," according to Waldman. "Now all of this might not mean anything. She may prove to be a strong advocate of Roe v. Wade. But it"s telling that the abortion interest groups took sides without knowing anything about her abortion
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Immune System Link To Schizophrenia Identified By UCLA Collaboration
Schizophrenia is a devastating mental disease, thought to be caused by the interaction of both genetic and environmental factors. Because there is no biochemical test that can identify the disorder, physicians rely upon the recognition of its symptoms - which can include auditory hallucinations and paranoia - in order to make their diagnosis.
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NICE Announces Review Of Its Skin Cancer Guidance

The National Institute for Health and Clinical Excellence (NICE) has announced that it will convene a guidance development group to formally review the recommendations relating to the diagnosis and removal of "low risk" basal cell carcinomas (BCCs) in primary care in its guidance Improving Outcomes in Cancer for people with skin tumours including melanoma (2003). Early in 2009 NICE was made aware of difficulties arising from the implementation of one aspect of its guidance. These were particularly in relation to the arrangements under which GPs could remove "low risk" BCCs and how services for skin cancer patients were being commissioned. Some GPs believed that the requirements, especially attendance at hospital multidisciplinary team meetings, were unnecessarily onerous and in some areas it was believed that there was a threat to GP minor surgery in general. As a result of these concerns, NICE held a meeting in April 2009, chaired by the National Cancer Director, Professor Mike Richards and including representatives of some of the key stakeholder groups involved in implementing the NICE guidance including the Royal College of General Practitioners (RCGP), British Medical Association and British Association of Dermatology (BAD). A number of important issues were clarified at this meeting but NICE feels that further formal review is needed. Dr Fergus Macbeth, Director of the Centre for Clinical Practice at NICE, said: "It is vital that patients are accurately diagnosed, receive appropriate treatment and avoid unnecessary or incomplete surgery. We have listened to the concerns of our stakeholders about the difficulty of implementing the recommendations in the guidance around the diagnosis and removal of low risk BCCs in primary care. We have also taken into account the fact that the management of skin conditions in general is an important part of all GPs" workload, for which they are trained, and that all GPs may undertake some minor procedures - such as curettage, cryotherapy and electrocautery - within their basic contract, and some GPs also carry out "minor surgery". It is important to point out that neither the original guidance nor any revisions to it will change this situation. What the expert group will specifically consider are the recommendations in the NICE guidance about the diagnosis and removal of low risk BCCs in primary care. Therefore, the recommendation in the guidance that patients with a suspected malignant melanoma, squamous cell carcinoma or high risk BCC should be referred to the Local Skin Cancer Multidisciplinary Team for diagnosis and management will not be reviewed." Dr Julia Verne, Deputy Regional Director of Public Health (South West Region) and Director of the South West Public Health Observatory, who chaired the original guidance development group, has agreed to chair this new group, which will consider the research evidence published since the launch of the NICE guidance. NICE


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