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Kessler Foundation Research Center Study Provides Insight Into One Of The Most Challenging Symptoms Following A Traumatic Brain Injury
A recent study by Kessler Foundation Research Center published in Brain Injury, the official journal of the International Brain Injury Association, uncovered the possible cause of cognitive fatigue in patients suffering from traumatic brain injury (TBI). Cognitive fatigue has been shown to be one of the most challenging symptoms following TBI, greatly affecting everyday life activities such as work and school. The study also addressed the difficult task of measuring cognitive fatigue through the use of functional MRI (fMRI), an advanced imaging technology. In addition to civilians with TBI, methodology from the study could potentially be used in VA Hospitals to improve the lives of the estimated 300,000 U.S. Iraq and Afghanistan war veterans who suffer from brain injury. Cognitive fatigue is a highly prevalent condition, with 73 percent of TBI patients reporting significant levels of fatigue even five years post-injury.
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Is 31P MRS A Useful Tool For Evaluating Early Acute Hepatic Radiation Injury?
Acute hepatic radiation injury could lead to necrosis of hepatocytes, fatty degeneration and hepatic fibrosis. At the present, the gold standard test is liver biopsy. However, this procedure is invasive, uncomfortable for the patients and sometimes results in serious complications. 31P magnetic resonance spectroscopy (MRS) has been used to study liver metabolism in vivo for several years. A research team led by Jian-Shan Mao from Zhejiang University investigated whether changes of 31P MRS in the liver with early acute radiation injury were related to the liver damage score (LDS) and pathologic changes. They also determined the value of 31P MRS in detecting early acute hepatic radiation injury, and identified the most valuable phosphorylated metabolite for detecting acute hepatic injury. Their study was published on June 14, 2009 in the World Journal of Gastroenterology.
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GSK's Pazopanib Significantly Delayed Tumour Progression In Patients With Advanced Kidney Cancer
Today, GlaxoSmithKline (GSK) announced the results of a Phase III study demonstrating that pazopanib reduced the risk of tumour progression or death by 54% compared to placebo.1
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Micronics Receives Patent On Rapid Thermocycling Methodology For Molecular Diagnostics

Micronics, Inc. announced that it has been issued a letters patent from the United States Patent and Trademark Office (USPTO) for a system and method for performing rapid thermocycling on a microfluidic device. The new patent has broad utility across the life sciences sector with particular application in point of care molecular diagnostics. The patent is entitled "System and method for heating, cooling and heat cycling on a microfluidic device," and is USPTO number 7,544,506 (the "506 case). The newly issued patent identifies an integrated system for performing a complete polymerase chain reaction (PCR) temperature cycle in less than 15 seconds using a microfluidic device that is made of lowest cost plastics. The system integrates a peltier-type heating, cooling and heat cycling exchange system on a disposable device using fluidic flow and the properties of selected plastic materials. This greatly simplifies both the cost and the size of a system needed to perform thermocycling. Historically, the process of thermocycling - the method that permits segments of DNA to be amplified using the PCR process - has involved complex and relatively expensive instruments operated by skilled technicians. In the "506 case, the disposable microfluidic cartridge makes it possible to perform PCR or rtPCR in a fraction of the time of commercial systems in use today. In Micronics" molecular diagnostic devices, all reagents required for a diagnostic test generally are incorporated into the disposable device. Micronics is advancing a point of care molecular diagnostic platform called the PanNAT system that employs disposable cartridges and a small, lightweight, easy to operate instrument. Using microfluidics, the Company is able to substantially reduce the volumes of sample and reagents required to produce a test result, generally within a fraction of the time and cost that traditional reference lab and bench top methods require. Micronics


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