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Swine Flu Daily Update Issued At: 11am Wednesday 8 July 2009. Wales
-- The NPHS influenza surveillance scheme, which records reports of diagnoses of flu from more than 300 GP practices across Wales, shows low levels of influenza activity in all parts of Wales. Further detail can be found on the NPHS website.
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Radiant Research, Inc. Prepares For Upcoming H1N1 Vaccine Trials
Radiant Research, Inc. announced that it is actively recruiting subjects and establishing operational plans for upcoming H1N1 vaccine trials. The World Health Organization declared the H1N1 influenza outbreak a pandemic, and the CDC has shipped virus samples to several manufacturers with the hope of having vaccine available to the general public by the fall. Manufacturers will need to complete clinical trials prior to release of vaccine to the public.
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BSI-201 Enters Phase III In Metastatic Triple Negative Breast Cancer
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its wholly owned subsidiary, BiPar Sciences, announced the initiation of the pivotal Phase III trial for BSI-201 in combination with chemotherapy in patients with metastatic triple-negative breast cancer (mTNBC), defined by tumors lacking expression of estrogen, progesterone receptors and without over-expression of HER2. BSI-201 is a novel investigational targeted therapy which inhibits poly (ADP-ribose) polymerase (PARP1), an enzyme involved in DNA damage repair.
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Infant Deaths Higher Among Deprived Communities And Ethnic Minorities

Rates of infant death remain high in parts of England, largely among deprived communities and ethnic minorities, finds a study published on bmj.com today. Despite government targets to reduce the gap in infant mortality, recent data indicate that the rates of both infant and perinatal mortality (death before, during or shortly after birth) remain high in many primary care trusts (PCTs) across England. PCTs with the worst infant mortality rates have been assigned "Spearhead" status by the Department of Health, but it is unclear whether such outcomes arise from poor service provision and lack of expenditure or from patient demographics such as deprivation or ethnicity. So a team of researchers obtained data on the number of infant and perinatal deaths, ethnicity, deprivation, maternal age, spending on maternal services, and "Spearhead" status for all 303 PCTs in England. They used this data to explain differences in infant and perinatal mortality between PCTs and identify outlier trusts where outcomes were worse than expected. Over a three-year study period, they found rates of infant mortality varied by PCT from 1.4 to 10.83 deaths per 1,000 live births, and perinatal mortality varied from 3.93 to 16.66 per 1,000 births. A combination of deprivation, ethnicity and maternal age explained 80.5% of the differences in outcome between PCTs. In contrast, variation in PCT spending on maternal services did not explain any of the observed differences. Two PCTs had higher than expected rates of perinatal mortality, but neither had "Spearhead" status. The reasons for this are not clear, say the authors, and further local scrutiny is required in order to ascertain the likely causes and potential solutions for these extreme results. On the basis of these findings, most PCTs can be confident that the social conditions and ethnicity of the communities they serve are more important determinants of these particular health outcomes than current variation in levels of expenditure on maternity services, say the authors. Nevertheless, the absolute rates of infant and perinatal mortality remain high in parts of England, and the burden of avoidable deaths remains largely with deprived communities and ethnic minorities, they conclude. Link to Paper British Medical Journal


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