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Advance Toward New Drugs That Turn Genes On And Off
Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of other disorders. Acting like an "on-off switch," the medications might ratchet up the production of proteins in genes working at abnormally low levels or shut off genes producing an abnormal protein linked to disease. Their report is in the current issue of ACS Chemical Biology, a monthly journal.
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One Stop Breast Clinics Best For Women
High-quality one-stop breast clinics could be the most effective way to spot breast cancer early, a study published in the British Journal of Cancer * reveals today (Wednesday).
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MicroRNAs Grease The Cell's Circadian Clockwork
Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. A large number of circadian genes are expressed by organs such as the liver, whose activity needs to be precisely regulated over the course of the day. A team of researchers of the National Centre of Competence in Research Frontiers in Genetics, based at the University of Geneva, Switzerland, reveals that an important regulator of this molecular oscillator is a specific microRNA. The latter belongs to a class of small RNA molecules that regulate the production of proteins in our cells. Thus far, little was known about their function within the circadian clockwork. The study by Ueli Schibler"s team, published in the 1st June edition of Genes & Development, fills in this important gap.
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Indiana U. Expert Says Nation's Physicians Support National Health Insurance

President Barack Obama spoke to the American Medical Association (AMA) recently addressing concerns about health insurance reform and the whole nation, including physicians from coast to coast, listened. "A general consensus seems to exist that the AMA will not support a public health insurance, option. Since the AMA bills itself as "the voice of physicians," by taking an anti-public insurance stance, the AMA is fostering the notion that a majority of physicians would be against comprehensive health care reform, including a public option. But our research indicates that on this issue, the AMA is not speaking for physicians," said Aaron Carroll, M.D., on Monday in response to Obama"s speech at the AMA. Dr. Carroll is director of the Indiana University Center for Health Policy and Professionalism (CHPPR), associate professor of pediatrics at the IU School of Medicine and a pediatrician at Riley Hospital for Children. A study conducted by CHPPR at the Indiana University School of Medicine and published last year in the Annals of Internal Medicine found that 59 percent of physicians would support government legislation for National Health Insurance, a much more radical type of reform than that proposed by the Obama administration. Only 32 percent of physicians opposed national health insurance, according to the study. The CHPPR survey of 2,200 physicians showed a 10 percent increase in support for national health insurance from a previous survey. Nearly every medical specialty showed an increase in levels of support for national health insurance. With the exception of radiologists, anesthesiologists and surgical subspecialists, a majority of every medical specialty now support national health insurance, according to the study. "While the AMA may oppose a public insurance option, there is no evidence that physicians do," said Dr. Carroll, a health services researcher who is a Regenstrief Institute affiliated scientist. Cindy Fox Aisen Indiana University


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