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Mouse Study Indicates Immune Cells From Spleen May Be Essential In Healing Heart Attack Damage
It takes a spleen to mend a broken heart - that"s the conclusion of a surprising new report from researchers at the Massachusetts General Hospital (MGH) Center for Systems Biology, directed by Ralph Weissleder, MD, PhD. In the July 31 issue of Science the team reports how, in following up an intriguing observation, they discovered an unexpected reservoir of the immune cells called monocytes in the spleen and went on to show that these cells are essential to recovery of cardiac tissue in an animal heart attack model.
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Sanofi Pasteur Begins Shipments Of Fluzone(R), Influenza Virus Vaccine For 2009 - 2010 Seasonal Influenza
Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced that it has shipped the first doses of the 2009-2010 formulation of Fluzone((R)), Influenza Virus Vaccine. Fluzone vaccine is indicated for active immunization in people 6 months of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the seasonal influenza vaccine. Fluzone vaccine is the only vaccine licensed in the United States for children as young as 6 months of age through adults.
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National Bug Busting Day Hotline Confirmed, UK
On Monday June 15th 2009, it"s the Department of Health"s National Bug Busting Day. It"s the day for families everywhere to check their hair for traces of head lice and nits. In support of this Department of Health incentive, The Hairforce are setting up a Head Lice Check & Clear Hotline (0844 848 5948) for people to call-in and listen to advice about checking and clearing hair.
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Expression Of Myoglobin In Human Cancers

A group led by Dr. Alberto Bardelli at The University of Turin Medical School reports that myoglobin may protect against the stresses of tumor growth. This study can be found in the July 2009 issue of the American Journal of Pathology. Myoglobin plays an important role in muscle cells by both transporting oxygen and preventing cell damage by scavenging free radicals. Tumor cells often survive in hypoxic (low oxygen), high free radical environments, despite these stresses on tumor growth. Flonta et al hypothesized that certain cancers may express myoglobin to survive the conditions associated with tumor growth. Indeed, human epithelial tumors, including breast, lung, ovary, and colon carcinomas, expressed high levels of myoglobin at early stages of development. In addition, myoglobin was induced in cell lines subjected to hypoxia, oxidative stress, and mitogenic stimulation. Myoglobin expression in carcinomas may therefore protect against the stresses of tumor growth. Dr. Bardelli and colleagues postulate that "should myoglobin prove to play a causative role in tumor progression, ò€¦ it is tempting to speculate that targeting one or more of its multiple functions by pharmacological agents or more advanced molecular tools could represent a novel therapeutic strategy in oncology." Flonta SE, Arena S, Pisacane A, Michieli P, Bardelli A: Expression and Functional Regulation of Myoglobin in Epithelial Cancers. Am J Pathol 2009, 174: 2611-2616 Angela Colmone American Journal of Pathology


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