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The Characteristics Of Clarithromycin-Resistant Helicobacter pylori
Clarithromycin is currently one of the antibiotics used for eradication of Helicobacter pylori. However, reports of H. pylori resistance to this antibiotic are increasing worldwide. Clarithromycin resistance has been attributed to the presence of mutations in the 23S rRNA gene, a component of the ribosome that is the protein manufacturing machinery of all living cells. There is little information on the prevalence and characteristics of clarithromycin resistance in H. pylori strains isolated from Malaysian patients.
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Study To Follow Pregnant Women To Better Understand Causes, Early Signs Of Autism
NIH and the advocacy group Autism Speaks are enrolling 1,200 pregnant women who have other children with autism spectrum disorders to participate in a large study that aims to identify early signs of the condition and its possible causes, the Wall Street Journal reports. Women who participate in the study -- known as the Early Autism Risk Longitudinal Investigation, or EARLI, study -- will be monitored throughout their pregnancies, and their infants will be monitored until age three. The Centers for Disease Control and Prevention estimates that one in 150 children in the U.S. has an autism spectrum disorder, which includes autism, Asperger"s syndrome and pervasive developmental disorders. The study will focus on women who already have one child with an autism spectrum disorder because such women have a higher chance of having another child with the condition. Craig Newschaffer, the study"s lead investigator and a department chair at Philadelphia"s Drexel University School of Public Health, said, "By studying families who are already affected by autism, we feel we have the best chance at learning how genetics and environmental factors could work together to cause autism." Autism usually is characterized by social interaction and communication impairments, as well as unusual interests or behaviors. Although there is no cure for autism, its symptoms can be improved through therapy and medication, the Journal reports.According to Newschaffer, researchers throughout the study will collect blood and urine for DNA analysis. Samples also will be collected from the umbilical cord, placenta and meconium -- the infant"s first stool -- after birth. Infants born during the study will be provided with a series of developmental assessments, and older siblings with autism also could receive assessments to confirm their diagnosis (Corbett Dooren, Wall Street Journal, 6/9).
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Phase III Study Showed Lucentis Improved Vision In Patients With Branch Retinal Vein Occlusion
Genentech, Inc. announced that the Phase III study BRAVO showed Lucentis® (ranibizumab injection) improved vision, as measured by the primary endpoint of mean change from baseline in best-corrected visual acuity at six months, in patients with macular edema due to branch retinal vein occlusion. The safety profile of Lucentis was consistent with previous experience and no new adverse events related to Lucentis were observed in the study. Retinal vein occlusion (RVO) is a common cause of vision loss that occurs when blood flow through a retinal vein becomes blocked, such as by a blood clot.
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Death Penalty And Mental Illness: Families Of Victims Speak Out At National Convention; "Double Tragedies" Report Released

For the first time, families of murder victims have joined with families of persons with mental illness who have been executed to speak out against the death penalty. Double Tragedies, a report being released today at a special session on the first day of the annual convention of the National Alliance on Mental Illness (NAMI), calls the death penalty "inappropriate and unwarranted" for people with severe mental disorders and "a distraction from problems within the mental health system that contributed or even directly lead to tragic violence." The report calls for treatment and prevention, not execution. It is available online at http://www.nami.org/doubletragedies. The report, a joint project of NAMI and Murder Victims" Families for Human Rights (MVFHR), is based on extensive interviews with 21 family members from 10 states: California, Florida, Georgia, Illinois, Louisiana, Maine, Massachusetts, North Carolina, Tennessee and Texas. "Family opposition to the death penalty is grounded in personal tragedy," said MVFHR executive director Renny Cushing. "In the public debate about the death penalty and how to respond in the aftermath of violent crime, these are the voices that need to be heard." "Most people with mental illness are not violent," said NAMI executive director Mike Fitzpatrick. "When violent tragedies occur they are exceptional, because something has gone terribly wrong, usually in the mental health care system. Tragedies are compounded and all our families suffer." The report identifies an "intersection" of family concerns and makes four basic recommendations: - Ban the death penalty for people with severe mental illnesses. - Reform the mental health care system to focus on treatment. - Recognize the needs of families of murder victims through rights to information and participation in criminal or mental health proceedings. - Families of executed persons also should be recognized as victims and given the assistance due to any victims of traumatic loss. At least 100 people with mental illness have been put to death in the United States and hundreds more are awaiting execution. NAMI


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